13 documents found, page 1 of 2
Sedentary behaviour impairs skeletal muscle repair modulating the inflammatory ...
Teixeira, Eduardo; Garcia, Juliana; Bovolini, António; Carvalho, Ana; Pacheco, Júlio; Duarte, José A.This study investigated whether sedentary behaviour modulates skeletal-muscle repair and tissue inflammatory response after cardiotoxin (CTX)-induced injury. Singly caged rats spent 8 weeks either as a sedentary group (SED, n = 15) or as a control group (EX, n = 15)—caged with running wheels for voluntary running. All rats had each tibial anterior muscle infused either with CTX (CTX; right muscle) or saline sol...
Exercise training counteracts the cardiac metabolic remodelling induced by expe...
Morais, Filipe; Nogueira-Ferreira, Rita; Rocha, Hugo; Duarte, José A.; Vilarinho, Laura; Silva, Ana F.; Leite-Moreira, Adelino; Santos, MárioExercise training provides several cardiovascular benefits in both physiological and pathological conditions; however, its use as a therapeutic tool for pulmonary arterial hypertension (PAH) has been poorly explored. This study aimed to extend the comprehension of the cardioprotective effects of exercise training in the set of PAH focusing on the metabolic changes promoted by exercise in the right ventricle (RV...
Effects of Age and Lifelong Moderate-Intensity Exercise Training on Rats' Testi...
Silva, Joana V.; Santiago, Joana; Matos, Bárbara; Henriques, Magda C.; Patrício, Daniela; Martins, Ana D.; Duarte, José A.; Ferreira, RitaAging is associated with testicular morphological and functional alterations, but the underlying molecular mechanisms and the impact of physical exercise are poorly understood. In this study, we examined the effects of age and lifelong moderate-intensity exercise on rat testis. Mature adults (35 weeks) and middle-aged (61 weeks) Wistar Unilever male rats were maintained as sedentary or subjected to a lifelong m...
Chronic exercise training attenuates prostate cancer-induced molecular remodell...
Matos, Bárbara; Patrício, Daniela; Henriques, Magda C.; Freitas, Maria J.; Vitorino, Rui; Duarte, Iola F.; Howl, John; Oliveira, Paula; Seixas, FernandaPurpose: Prostate cancer is a major cause of cancer-related death in males worldwide and, in addition to impairing prostate function, also causes testicular adaptations. In this study, we aim to investigate the preventive effect of exercise training on PCa-induced testicular dysfunction. Methods: As a model, we used fifty Wistar Unilever male rats, randomly divided in four experimental groups. Prostate cancer w...
Port-a-cath catheter embolization to distal pulmonary artery branches : two tai...
Francisco, Ana Rita; Duarte, José A.; Oliveira, Eduardo Infante deSeveral types of intravascular devices and catheters are frequently used for long-term drug therapy, especially for oncological patients. As a result, complications are becoming increasingly common, namely catheter embolization. Retrieving these devices is important, as embolized fragments may lead to serious consequences, such as arrhythmias, myocardial injury, thrombosis, infection, and even perforation and d...
Effects of resistance exercise on endothelial progenitor cell mobilization in w...
Ribeiro, Fernando; Ribeiro, Ilda P.; Gonçalves, Ana C.; Alves, Alberto J.; Melo, Elsa; Fernandes, Raquel; Costa, Rui; Ribeiro, Ana B. SarmentoThis study aimed to determine the effect of a single bout of resistance exercise at different intensities on the mobilization of circulating EPCs over 24 hours in women. In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1α), vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α) and erythropoietin (EPO) were measured as potential mechanisms for exercise-induced...
Are corticosteroids useful in all degrees of severity and rapid recovery of Bel...
Ferreira, Margarida; Firmino, Machado J.; Marques, Elisa A.; Santos, Paula Clara; Duarte, José A.The results provide preliminary evidence that corticosteroids were not effective in all grades of dysfunction and for achieving a rapid remission in the early phase of BP, highlighting the need to define standard and rigorous criteria to prescribe corticosteroids in these patients. The main aim of this study was to investigate whether the use of corticosteroids better associated than paralleled with neuromuscul...
Prognostic factors for recovery in Portuguese patients with Bell’s palsy
Ferreira, Margarida; Firmino-Machado, João; Marques, Elisa A.; Santos, Paula Clara; Simões, Ana Daniela; Duarte, José A.The main aim of this study was to identify the prognostic factors that contribute to complete recovery at 6 weeks and 6 months in patients with Bell’s palsy. Material and Methods: This is a prospective, longitudinal, and descriptive study that included 123 patients diagnosed with facial nerve palsy (FNP) at a hospital in Guimarães, Portugal. However, only 73 patients with Bell’s palsy (BP) were included in the ...
A breakthrough on Amanita phalloides poisoning: an effective antidotal effect b...
Garcia, Juliana; Costa, Vera M.; Carvalho, Alexandra T.P.; Silvestre, Ricardo; Duarte, José A.; Dourado, Daniel F.A.R.; Arbo, Marcelo D.Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. α-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure. In silico studies included docking and molecular dynamics simulation coupled to molecular mechanics with generalized Born and surface area method energy decomposition on ...
Cumulative Mitoxantrone-Induced Haematological and Hepatic Adverse Effects in a...
Rossato, Luciana G.; Costa, Vera M.; Dallegrave, Eliane; Arbo, Marcelo; Dinis-Oliveira, Ricardo J.; Santos-Silva, Alice; Duarte, José A.Mitoxantrone (MTX) is an antineoplastic agent that can induce hepato- and haematotoxicity. This work aimed to investigate the occurrence of cumulative early and late MTX-induced hepatic and haematological disturbances in an vivo model. A control group and two groups treated with three cycles of 2.5 mg/kg MTX at days 0, 10 and 20 were formed. One of the treated groups suffered euthanasia on day 22 (MTX22) to eva...