23 documents found, page 1 of 3

Subacute Meningitis: A Rare Presentation of Brucellosis

A young male adult presented with a two-week-long history of myoarthralgia, vomiting, febrile sensation, holocranial headache with photophobia, neck stiffness, anorexia, and weight loss. He worked as a butcher in a local slaughterhouse, and two of his coworkers had recently been diagnosed with brucellosis. On his fourth visit to the Emergency Department (ED), fever was observed for the first time. He was admitt...

Osteoarticular Infections in Infants Under 3 Months of Age

Background: Acute osteoarticular infections (OAI) in infants under 3 months of age (≤3M) are rare and remain a diagnostic challenge. Orthopedic complications and functional sequelae have been less well described in this age group. Our aims were to evaluate trends in aetiology, management, and outcomes of OAI ≤ 3M, and to compare these younger children who have OAI with older children. Methods: A longitudinal ob...

LiDAR – Tudo na luz é informação

O que têm em comum o caminho da lua no mar e a condução autónoma de veículos? A reflexão difusa da luz em superfícies rugosas e materiais heterogêneos é responsável pela visibilidade de objetos que não conseguiríamos ver de acordo com a lei de Snell. O mesmo fenómeno ótico também está na base do funcionamento de sensores remotos chamados LIDARs (abreviação de Light Detection And Ranging) que surgiram nos anos 6...

Pulse Consumption among Portuguese Adults: Potential Drivers and Barriers towar...

The transition from diets rich in animal products to plant-based protein foods—like pulses—is crucial, for both environmental sustainability and human health. The aim of this study was to characterize the current consumption and to describe the drivers of and barriers to pulse intake in Portugal. Using a quantitative approach, a semi-structured questionnaire was distributed online, and 1174 valid responses were...

Osteoarticular Infections in Paediatric Sickle Cell Disease: in the Era of Mult...

New Prospects for the Management of Cardiovascular Effects of Tyrosine Kinase I...

The use of tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukemia has significantly altered the prognosis of this disease, enabling close to normal life expectancy. Despite their undeniable benefits, the use of TKIs is associated with an increased risk of side effects on the cardiovascular system, particularly of atherothrombotic events. It is therefore necessary to understand and preve...

In Silico Discovery of a Substituted 6-Methoxy-quinalidine with Leishmanicidal ...

There is an urgent need for the discovery of new antileishmanial drugs with a new mechanism of action. Type 2 NADH dehydrogenase from Leishmania infantum (LiNDH2) is an enzyme of the parasite’s respiratory system, which catalyzes the electron transfer from NADH to ubiquinone without coupled proton pumping. In previous studies of the related NADH: ubiquinone oxidoreductase crystal structure from Saccharomyces ce...

A single-cysteine mutant and chimeras of essential Leishmania Erv can complemen...

Mia40/CHCHD4 and Erv1/ALR are essential for oxidative protein folding in the mitochondrial intermembrane space of yeast and mammals. In contrast, many protists, including important apicomplexan and kinetoplastid parasites, lack Mia40. Furthermore, the Erv homolog of the model parasite Leishmania tarentolae (LtErv) was shown to be incompatible with Saccharomyces cerevisiae Mia40 (ScMia40). Here we addressed stru...

Claudicação da Marcha - Três Casos, Três Diagnósticos...

Introdução: A claudicação da marcha na criança é frequente tendo múltiplas etiologias (infeciosa, traumática, inflamatória, mecânica ou neoplásica). Apresentam-se três casos de gonalgia com diagnósticos distintos. Caso clínico:Caso clínico 1: Rapaz de 2 anos, com gonalgia com 4 dias de evolução, sinais inflamatórios e limitação funcional. Sem leucocitose, PCR 87mg/L, VS 68mm/h e ecografia com derrame articular....

Accuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocali...

BACKGROUND AND AIMS: Mucosal healing and histological remission are different targets for patients with ulcerative colitis, but both rely on an invasive endoscopic procedure. This study aimed to assess faecal calprotectin and neutrophil gelatinase B-associated lipocalin as biomarkers for disease activity in asymptomatic ulcerative colitis patients. METHODS: This was a multicentric cross-sectional study includin...