This study was partially supported by the National Institute of Science and Technology for Viral Haemorrhagic Fevers-INCT-FHV INCT-FHV. (MCT/CNPq/FNDCT/CAPES/FAPESPA No. 15/2008) process 573739/2008-0, CNPq process 501549/2003-0, and CNPq process 301641/2010-2.; Universidade de S?o Paulo. Faculdade de Medicina. Laborat?rio da Disciplina de Patologia de Mol?stias Transmiss?veis. S?o Paulo, SP, Brasil / Instituto...
Rheumatoid arthritis (RA) is a chronic condition that is frequent in patients living in tropical areas exposed to leishmaniasis. RA therapy involves immunosuppressant drugs such as methotrexate (MTX), monoclonal antibodies (mAbs) and prednisone. We report an unusual presentation of cutaneous (CL) or mucocutaneous leishmaniasis (ML) in RA patients from an endemic area of leishmaniasis. A 51-year-old woman noted ...
Federal do Par? University. Tropical Medicine Unit. Bel?m, PA, Brazil.; Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.; State University of S?o Paulo. Faculty of Medicine. S?o Paulo, SP, Brazil.; State University of S?o Paulo. Faculty of Medicine. S?o Paulo, SP, Brazil.; State University of S?o Paulo. Faculty of Medicine. S?o Paulo, SP, Brazil.; Minist?rio d...
OBJECTIVES: The aim of this study was to describe the pattern of expression of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in skin biopsies of patients with American tegumentary leishmaniasis (ATL) caused by Leishmania braziliensis. METHODS: This prospective study evaluated 12 patients with ATL caused by Leishmania braziliensis confirmed by polymerase chain reaction. Immunohistochemistry was per...