5 documents found, page 1 of 1
Loss of postprandial insulin clearance control by Insulin-degrading enzyme driv...
Borges, Diego O; Patarrão, Rita S; Ribeiro, Rogério T.; de Oliveira, Rita Machado; Duarte, Nádia; Belew, Getachew Debas; Martins, MadalenaSystemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is involved in the intracellular mechanisms underlying IC. The liver is a major player in IC control yet the role of hepatic IDE in glucose and lipid homeostasis remains unexplored. We hypothesized that IDE governs postprandial IC and hepatic IDE dysfunction am...
Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Dama...
Duarte, Nádia; Coelho, Inês; Holovanchuk, Denys; Inês Almeida, Joana; Penha-Gonçalves, Carlos; Paula Macedo, MariaDipeptidyl peptidase-4 (DPP-4 or clusters of differentiation [CD]26) is a multifunctional molecule with established roles in metabolism. Pharmacologic inhibition of DPP-4 is widely used to improve glycemic control through regulation of the incretin effect. Colaterally, CD26/DPP-4 inhibition appears to be beneficial in many inflammatory conditions, namely in delaying progression of liver pathology. Nevertheless,...
How Inflammation Impinges on NAFLD: A Role for Kupffer Cells
Duarte, Nádia; Coelho, Inês C.; Patarrão, Rita S.; Almeida, Joana I.; Penha-Gonçalves, Carlos; Macedo, M. PaulaNonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the ...
Carotid diseases
Pinheiro, Inês Müller; Marques, Gil; Duarte, Nádia; Gonçalves, Ana; Barroso, Pedro; Gonzalez, António; Ferreira, Maria JoséAbout 90% of the cases of extracranial cerebrovascular disease are due to atherosclerosis. The atherosclerosis plaques occur mainly in the carotid bifurcation and their most dreaded consequence is a stroke, which is the number one cause of morbilitity and permanent disability in Europe. It is also considered the second most important cause of dementia, the most important cause of epilepsy in the elderly and a f...
Peripheral arterial disease
Ferreira, Maria José; Barroso, Pedro; Duarte, NádiaPeripheral arterial disease is caused mainly by atherosclerosis, which leads to arterial stenosis and occlusions in the major vessels that supply the lower limbs. The classic symptom is intermittent claudication, which is characterized by muscle discomfort in the lower limb, caused by exercise and relieved by rest. An accurate diagnosis of peripheral arterial disease is achieved by obtaining the patients vascu...