Funding Information: PORTHOS study arises from a scientific partnership between the Portuguese Society of Cardiology, AstraZeneca and NOVA Medical School. The authors are especially grateful to all the institutional partners that collaborated at various levels: Associação de Apoio aos Doentes com Insuficiência Cardíaca (AADIC), GlobalSports, Maria Design, Missão Continente (Sonae), Unilabs and GE. For the colla...