178 documents found, page 1 of 18

Perceptions and experiences of directly observed treatment in tuberculosis: ins...

Objective: The demanding nature and psychosocial burdens of directly observed treatment (DOT) have opened a path to alternative strategies such as video-observed therapy (VOT), which offers comparable treatment outcomes and patient satisfaction while potentially saving time and reducing costs. The objective of this study was to evaluate the perceptions and experiences of patients and health care professionals r...

Urgent request for pretomanid label expansion to align with WHO guidelines and ...

Pretomanid is a key anti-TB drug included in the WHO list of essential medications. The current EMA-approved label for pretomanid restricts its use to the regimen comprising bedaquiline, pretomanid and linezolid (BPaL) and only for extensively drug-resistant-TB or multidrug-resistant TB, “when antibiotics used for the latter form of TB do not work or cause unacceptable side effects.” This restricted use implies...

Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis An...

Background: On the basis of recent clinical trial data for the treatment of drug-susceptible and drug-resistant tuberculosis (TB), the American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America have updated clinical practice guidelines for TB treatment in children and adults in settings in which mycobacterial cultures, mol...

European guidelines for the management of tuberculosis screening procedures in ...

"Background: This systematic review assesses the current available evidence across the WHO European region on the effectiveness and cost-effectiveness of the different approaches used for TB screening and also explores the facilitators and barriers that migrants face during screening programmes. Methods: We conducted an extensive, comprehensive, and systematic literature search across multiple databases, includ...

Expert perspectives on tuberculosis screening procedures for migrants

Objective: To evaluate the perspectives of tuberculosis experts from different countries regarding national screening procedures. Methods: This was a qualitative descriptive study. Data were collected by using electronic, anonymized surveys with experts in tuberculosis in seven different countries within two World Health Organization regions (Europe and Africa). Thematic analysis was employed. Results: The surv...

Use of putative hepatoprotective agents as an adjunct to anti-TB treatment in E...

"Background: Anecdotal information suggests that clinical practice regarding the use of putative hepatoprotective agents in TB treatment varies across countries in the WHO European Region. Methods: Between November 2023 and May 2024, we conducted a standardised questionnaire survey on the use of putative hepatoprotective agents in patients receiving TB treatment among Tuberculosis Network European Trials Group ...

Safety, Efficacy and Pharmacokinetics of daily optimised doses of Rifampicin fo...

"Background: Higher than standard doses of rifampicin could improve the treatment outcome of drug-susceptible tuberculosis without compromising the safety of patients. Methods: We performed a systematic review of prospective clinical studies including adults with pulmonary and extrapulmonary TB receiving rifampicin doses above 10mg/kg/day. We extracted the data on overall adverse events (AE), hepatic AE, sputum...

The importance of getting the dose right in the treatment of tuberculosis

Prescribing the optimal combination of anti-tuberculosis drugs at the right dose is a fundamental step to achieve successful treatment outcomes. To aid the decision, clinicians should consider multiple factors, such as body weight, age, results of drug susceptibility testing, risk of intolerance and potential drug-drug interactions. In this viewpoint, we outline different aspects of dose selection in the treatm...

Characterization of the fish acoustic communities in a Mozambican tropical cora...

Coral reefs are biodiversity hotspots in urgent need of protection in most areas of the tropical belt due to increasing local anthropogenic pressures and climate change. Sounds produced by fishes are an important component of soundscapes in these ecosystems, making passive acoustic monitoring (PAM) an effective tool to map the presence of target species or to estimate changes in biodiversity. The present study ...

Viewpoint on WHO implementation guidance on tuberculosis infection prevention a...