77 documents found, page 1 of 8
Tuberculosis in children under 5 years of age in a low-burden setting
Fronteira, Inês; Pacheco, Matilde; Vilichane, Ivinildo; Ricardo, Edgar; Aguiar, Pedro; Duarte, Raquel; Ferrinho, PauloPurpose: To describe the sociodemographic and epidemiological characteristics and healthcare utilization patterns—primary healthcare (PHC) use, emergency department (ED) visits, and hospital admissions—of children under 5 years of age born in Portugal between July 1, 2010, and June 30, 2021, and diagnosed with TB during the same period. Methods: This is a quantitative, observational cohort study of 58 children ...
European guidelines for the management of tuberculosis screening procedures in ...
Pinheiro, Marina; Valente, Carolina; Cruz, Margarida; Nascimento Moreira, David; Aguiar, Ana; Duarte, RaquelBackground: This systematic review assesses the current available evidence across the WHO European region on the effectiveness and cost-effectiveness of the different approaches used for TB screening and also explores the facilitators and barriers that migrants face during screening programmes. Methods: We conducted an extensive, comprehensive, and systematic literature search across multiple databases, includi...
Update in tuberculosis treatment: a scoping review of current practices
Lopes, Sofia R.; Marçal, Mariana; Fernandes, Nicole; Silva, Filipa; Barbosa, Pedro; Vieira, Mariana; Ramos, João Pedro; Duarte, RaquelBackground: Tuberculosis (TB) remains a significant global health challenge despite ongoing control efforts, particularly in the context of drug-resistant TB (DR-TB), where treatment success rates remain low, underscoring the need for new therapeutic options. This review synthesises current evidence, since the publication of the World Health Organization guidelines in 2022, on the safety and efficacy of existin...
Clinical standards for antimicrobial stewardship in TB care
Brehm, T T; Akkerman, O W; Sotgiu, G; Tiberi, S; Chang, K-C; Dheda, K; Duarte, Raquel; Vambe, D; Udwadia, Z F; Chesov, D; Mendelson, MBackground: While antimicrobial stewardship (AMS) is essential for combating antimicrobial resistance (AMR), TB-specific AMS strategies remain poorly defined. Methods: An international panel of 62 experts participated in a Delphi process. Using a 5-point Likert scale (5 = strong agreement; 1 = strong disagreement), participants evaluated 10 draft clinical standards developed by a core coordination team. A stand...
The importance of getting the dose right in the treatment of tuberculosis
Dudnyk, Andrii; Lutchmun, Wandini; Duarte, Raquel; Lange, Christoph; Svensson, Elin M.; on behalf of the UNITE4TB ConsortiumPrescribing the optimal combination of anti-tuberculosis drugs at the right dose is a fundamental step to achieve successful treatment outcomes. To aid the decision, clinicians should consider multiple factors, such as body weight, age, results of drug susceptibility testing, risk of intolerance and potential drug-drug interactions. In this viewpoint, we outline different aspects of dose selection in the treatm...
Perceptions and experiences of directly observed treatment in tuberculosis: ins...
Amorim, Diana; Ramos, João Pedro; Barbosa, Pedro; Vieira, Mariana; Duarte, RaquelObjective: The demanding nature and psychosocial burdens of directly observed treatment (DOT) have opened a path to alternative strategies such as video-observed therapy (VOT), which offers comparable treatment outcomes and patient satisfaction while potentially saving time and reducing costs. The objective of this study was to evaluate the perceptions and experiences of patients and health care professionals r...
Patient-reported outcomes in tuberculosis: a qualitative exploration of psychos...
Viegas, Pedro; Ferreira, Luís L.; Vieira, Mariana; Barbosa, Pedro; Ramos, João P.; Duarte, RaquelObjective: Personal experiences, perceptions, and views of patients are crucial in understanding the subjective impacts of diseases. The complexity and duration of tuberculosis treatment impose significant physical, emotional, social, and economic burdens, highlighting the need for person-centered, integrated care strategies that address stigma, fatigue, and accessibility to support well-being. Patient-reported...
Mapping risk and protective factors in tuberculosis-related stigma: a scoping r...
Vieira, Mariana; Barbosa, Pedro; Ramos, João Pedro; Castro, Marta; Torres, Dulce; Duarte, RaquelDespite global efforts to end tuberculosis (TB), slow declines in incidence and mortality rates persist, partly due to entrenched social and structural challenges. TB-related stigma is a critical barrier to effective TB prevention and treatment. However, existing frameworks often overlook broader structural and intersectional influences, underscoring the need for a comprehensive analysis of the social and struc...
Expert perspectives on tuberculosis screening procedures for migrants
Pinheiro, Marina; Moreira, David N.; Aguiar, Ana; Duarte, RaquelObjective: To evaluate the perspectives of tuberculosis experts from different countries regarding national screening procedures. Methods: This was a qualitative descriptive study. Data were collected by using electronic, anonymized surveys with experts in tuberculosis in seven different countries within two World Health Organization regions (Europe and Africa). Thematic analysis was employed. Results: The surv...
Optimising non-pharmacological interventions in people with non-tuberculous myc...
Sulaiman, Naif; Martins, Beatriz; Moreira-Sousa, Diana; Aguiar, Ana; Hurst, John R.; Brown, James; Duarte, Raquel; Lipman, MarcIntroduction: Treatment of non-tuberculous mycobacterial pulmonary disease (NTM-PD) is often complex, relying on long treatment courses with multiple antibiotics, which are associated with treatment intolerance and failure. Current guidelines provide limited insight into non-pharmacological treatment, which is believed to be an important component of symptom control and is related to treatment outcomes with an ...