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Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Act...

Vojtek, Martin; Martins, Clara B.; Ramos, Raquel; Duarte, Sara Gomes; Ferreira, Isabel M. P. L. V. O.; Carvalho, Ana L. M. Batista de

Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10-20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel drug entities with improved tolerability and selectivity profiles, as w...

Date: 2023   |   Origin: Estudo Geral - Universidade de Coimbra
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