10 documents found, page 1 of 1

IMPACTO DA SÍNDROME METABÓLICA NO TRANSPLANTE AUTÓLOGO DE CÉLULAS TRONCO HEMATO...

RESUMO INTRODUÇÃO: Entre as possíveis complicações em pacientes submetidos ao transplante de células-tronco hematopoiéticas estão os distúrbios metabólicos. OBJETIVOS: verificar a prevalência de síndrome metabólica e de seus componentes entre os pacientes internados para a realização do transplante de células-tronco hematopoiéticas e seu impacto no tempo de hospitalização, complicações e desfecho clínico. METOD...

Wernicke's encephalopathy in a patient with non-Hodgkin's lymphoma post-Autolog...

SUMMARY Wernick's Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is rarely considered in patients submitted to this procedure. Considering that, the manuscript reports the clinical characteristics and the possible factors that predi...

Mobilization of hematopoietic progenitor cells for autologous transportation: c...

SUMMARY Selected patients with certain hematological malignancies and solid tumors have the potential to achieve long-term survival with autologous hematopoietic progenitor cell transplant. The collection of these cells in peripheral blood avoids multiple bone marrow aspirations, results in faster engraftment and allows treatment of patients with infection, fibrosis, or bone marrow hypocellularity. However, for...

Relevance of prognostic factors in the decision-making of stem cell transplanta...

ABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS. The aim of this study is to discuss the factors that can guide the decision-making on referring or not a patient to HSCT. Three cases of ...

Hodgkin’s Lymphoma - evaluation of patients submitted to Autologous transplanta...

SUMMARY The Autologous HSCT is an important alternative for refractory or recurrent HL patients in terms of survival and improved quality of life. This study analyzes the results of autologous BMT performed in HL patients in the Transplant Unit of the HUWC/ HEMOCE (Fortaleza - CE, Brazil). Fifty-two transplanted patients were studied from January 2009 to October 2015, among them, 30 men and 22 women, mean age o...

Association of oxidative stress and DNA damage with grafting time in patients w...

ABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were per...

Tumor suppressor p53 protein expression: prognostic significance in patients wi...

BACKGROUND: At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine the cause of this variability.OBJECTIVE: To evaluate ...

T-cell/myeloid mixed-phenotype acute leukemia with monocytic differentiation an...

Mixed phenotype acute leukemia is a rare subtype of leukemia that probably arises from a hematopoietic pluripotent stem cell. The co-expression of two of myeloid, B- or T-lymphoid antigens is the hallmark of this disease. Herein, the case of a 28-year-old female patient is reported who presented with hemoglobin of 5.8 g/dL, white blood cell count of 138 × 109/L and platelet count of 12 × 109/L. The differential...

Myelodysplastic syndrome versus idiopathic cytopenia of undetermined significan...

Serum concentrations of nitrite and malondialdehyde as markers of oxidative str...

BACKGROUND: Chronic myeloid leukemia is a neoplasm characterized by clonal expansion of hematopoietic progenitor cells resulting from the (9:22)(q34,11) translocation. The tyrosine kinase abl fusion protein,the initial leukemogenic event in chronic myeloid leukemia, is constitutively activated thus inducing the production of reactive oxygen species. Of particular relevance is the fact that an increase in reacti...