3 documents found, page 1 of 1
Cardiac molecular remodeling by anticancer drugs: Doxorubicin affects more meta...
Brandão, Sofia Reis; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria João; Rocha, Hugo; Carvalho, Félix; Ferreira, Rita; Costa, Vera MarisaDoxorubicin (DOX) and mitoxantrone (MTX) are classical chemotherapeutic agents used in cancer that induce similar clinical cardiotoxic effects, although it is not clear if they share similar underlying molecular mechanisms. We aimed to assess the effects of DOX and MTX on the cardiac remodeling, focusing mainly on metabolism and autophagy. Adult male CD-1 mice received pharmacologically relevant cumulative dose...
Molecular alterations underlying Doxorubicin’s Chronic Cardiotoxicity in a mous...
Reis Brandão, Sofia; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa
Pullulan microneedle patches for the efficient transdermal administration of in...
Fonseca, Daniela F. S.; Costa, Paulo C.; Almeida, Isabel F.; Dias-Pereira, Patrícia; Correia-Sá, Inês; Bastos, Verónica; Oliveira, HelenaThe present study reports the fabrication of dissolvable microneedle (MN) patches using pullulan (PL), a water-soluble polysaccharide with excellent film-forming ability, for the transdermal administration of insulin, envisioning the non-invasive treatment of diabetes. PL MNs patches were successfully prepared by micromoulding and revealed good thermal stability (Tdmax = 294 °C) and mechanical properties (>0.15...