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Addressing challenges to enhance clinical research in Portugal: insights from t...
Resende, Catarina; Abreu, Marta; Presa Ramos, José; Carda, José; Costa, Luís; Cardoso, Fátima; Pereira, Deolinda; Teixeira, Encarnação; Tonin, FernandaIntroduction Over the past decades, clinical research has evolved significantly, driven by advances in regulatory frameworks, technological innovations, and methodological approaches. In Portugal, while there has been progress - such as increased regulatory alignment with European standards and the adoption of digital trial management tools - various challenges remain. These may include, among others, limited a...
The effects of benralizumab on lung volumes and airway resistance in severe eos...
Gerardo, António Madeira; Alves, Carolina da Silva; Gomes, Margarida; Pardal, Cecília; Sokolova, Anna; Liberato, Hedi; Mendes, Ana; Tonin, FernandaIntroduction: Add-on biological monoclonal antibodies such as benralizumab (anti-IL-5Ra) are recommended by international guidelines to reduce exacerbations in severe eosinophilic asthma (SEA). However, few studies have assessed the impact of these therapies on lung function-related outcomes. Our goal was to evaluate the effectiveness of benralizumab on lung function, including lung volumes and airway resistanc...
Physical activity promotion in the community pharmacy: an opportunity for an ex...
Viegas, Ruben; Silva, Filipa; Nørgaard, Lotte Stig; Duarte-Ramos, Filipa; Mendes, Romeu; Alves da Costa, FilipaBackground: Physical inactivity is a major risk factor for the development of chronic diseases, and it is increasingly prevalent in the Portuguese population. Pharmacists' role in promoting physical activity (PA) is still not well established, although health promotion is foreseen by law in Portugal. Competing tasks and location where the pharmacy is embedded can hinder this promotion in their daily practice. O...
Experience and learning from the COVID-19 pandemic in Portugal: perceptions of ...
Advinha, Ana Margarida; Santos, Margarida Custódio dos; Duarte-Ramos, Filipa; Perdigão, Margarida; Santos, Patricia; Oliveira-Martins, SofiaBackground: During the COVID-19 pandemic, community pharmacy (CP) professionals were among those who experienced the greatest risk of contracting SARS-CoV-2, which forced major adaptations. Objectives: The objectives of the study were to describe the changes implemented in CP professionals during the pandemic, understand the perception of professionals about their experience, and explore changes to remain. Meth...
Correction: The meaning of lymphadenopathies during adjuvant durvalumab after c...
Pantarotto, Marcos; Barata, Rita; Coelho, Ricardo; Sousa, Virginia; Carvalheiro, Catarina; Rolim, Ines; Garrido, Patricia; GIl, NunoThis article has been corrected at the request of the authors to include Virginia Sousa as the fourth author as she was erroneously omitted during the submission process. The authors deeply regret that this error was not identified and addressed prior to publication.
The initial journey of patients with metastatic pancreatic cancer (PaCTO projec...
Barros, Anabela G.; Mansinho, Hélder; Couto, Nuno; Teixeira, Manuel R.; Tonin, Fernanda; Francisco, Rudolfo; Duarte-Ramos, FilipaABSTRACT - Introduction: We aimed to characterize the initial healthcare journey of metastatic pancreatic ductal adenocarcinoma (mPDAC) patients in Portugal, including healthcare provision and factors affecting therapeutic decisions, namely BRCA mutation testing. Methods: This is a descriptive cross-sectional, web-based survey using a convenience sampling approach. Portuguese oncologists and pathologists who ro...
Optimizing the use of systemic corticosteroids in severe asthma (ROSA II projec...
Marques, João; Duarte-Ramos, Filipa; Ferreira, Manuel Branco; Lima, Ricardo; Lopes, Cristina; Sokolova, Anna; Tonin, Fernanda StumpfAlthough the prevalence of severe asthma is not high (5-10% of patients), it is responsible for a large part of the overall disease burden and costs (50-60% of total costs), especially if the condition remains uncontrolled (which occurs in around 40% of cases). Currently, for patients without disease control or presenting frequent exacerbations despite optimal therapy, add-on treatments, traditionally long-acti...
The meaning of lymphadenopathies during adjuvant durvalumab after chemoradiothe...
Pantarotto, Marcos; Barata, Rita; Coelho, Ricardo; Carvalheiro, Catarina; Rolim, Ines; Garrido, Patricia; GIl, Nuno; Duarte-Ramos, FilipaImmune-checkpoint inhibitors (ICIs) have become the mainstay of treatment for many malignancies. With this new strategy, relevant immune-related adverse events (irAEs) have been reported, some of which can be mistaken for disease progression. To better illustrate the current challenges in diagnosing and managing a patient under adjuvant ICI treatment, we present the case of a 67-year-old female patient with sta...
Dashboard COMPRIME-COMPRIM_MOV: monitorização espácio-temporal da Covid-19 em P...
Marques Da Costa, Nuno; Mileu, Nelson; Alves, André; Marques Da Costa, Eduarda; Rocha, Jorge; Abrantes, Patrícia; Freitas, Carlos; Sousa, PauloO interesse por informação credível e atualizada no âmbito da evolução pandémica conduziu à necessidade de desenvolver um instrumento que permitisse a disseminação de informação sobre o estado da difusão da COVID-19. No dashboard desenvolvido é integrada informação segundo quatro níveis territoriais desde março de 2020 até à atualidade. Suportada no ArcGIS Online, foram desenvolvidas outras soluções exteriores ...
Mobilidade e propagação do sars-cov-2 em Portugal continental: modelo explicati...
Marques Da Costa, Nuno; Mileu, Nelson; Marques da Costa, Eduarda; Alves, André; Freitas, Carlos; Rocha, Jorge; Abrantes, Patrícia; Gomes, EduardoA difusão do novo coronavírus tem importantes associações com a mobilidade da população. Recorrendo a modelos de regressão linear múltipla, com informação epidemiológica da Direção-Geral da Saúde (DGS) e dados de mobilidade disponibilizados pela Google, captura-se a relação causal existente entre alterações na mobilidade e a tendência de incidência de COVID-19 para várias escalas em Portugal, demonstrando-se qu...