8 documents found, page 1 of 1
Valorization of chicken feathers using aqueous solutions of ionic liquids
Polesca, Cariny; Passos, Helena; Neves, Bruno M.; Coutinho, João A. P.; Freire, Mara G.The poultry-processing industry generates large quantities of waste rich in keratin, a fibrous protein representing around 90 wt % of chicken feathers, which is currently disposed of in landfilling or incinerated. Keratin is commonly recognized as a renewable biopolymer resource used for biomaterials preparation (e.g., films and hydrogels) with interest for biomedical applications. Even though research on kerat...
Photo‐compartmentalized decellularized matrix‐hyaluronan hybrid units for pancr...
Monteiro, Maria V.; Henriques-Pereira, Margarida; Neves, Bruno M.; Duarte, Iola D.; Gaspar, Vítor M.; Mano, João F.Tissue-derived decellularized extracellular matrix (dECM) provides unique biomolecular cues for bioengineering 3D tumor models with increasingly physiomimetic features. This biomimicry potential can be expanded by combining dECM with key components of native tissues, such as glycosaminoglycans (GAGs). Yet, this combination remains highly challenging, often requiring complex non-natural chemical modifications of...
Deep Eutectic Solvent Formulations and Alginate-Based Hydrogels as a New Partne...
Pedro, Sónia N.; Mendes, Maria S. M.; Neves, Bruno M.; Almeida, Isabel Filipa; Costa, Paulo; Correia-Sá, Inês; Vilela, Carla; Freire, Mara G.The transdermal administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is a valuable and safer alternative to their oral intake. However, most of these drugs display low water solubility, which makes their incorporation into hydrophilic biopolymeric drug-delivery systems difficult. To overcome this drawback, aqueous solutions of bio-based deep eutectic solvents (DES) were investigated to enhance the so...
Multi-Omic profiling of macrophages treated with phospholipids containing Omega...
Maurício, Tatiana; Aveiro, Susana; Guedes, Sofia; Lopes, Diana; Melo, Tânia; Neves, Bruno M.; Domingues, Rosário; Domingues, PedroIn recent years, several studies have demonstrated that polyunsaturated fatty acids have strong immunomodulatory properties, altering several functions of macrophages. In the present work, we sought to provide a multi-omic approach combining the analysis of the lipidome, the proteome, and the metabolome of RAW 264.7 macrophages supplemented with phospholipids containing omega-3 (PC 18:0/22:6; omega 3-PC) or ome...
Structural features and pro-inflammatory effects of water-soluble organic matte...
Almeida, Antoine S.; Ferreira, Rita M. P.; Silva, Artur M. S.; Duarte, Armando C.; Neves, Bruno M.; Duarte, Regina M. B. O.The impact of inhalable fine particulate matter (PM2.5, aerodynamic diameter < 2.5 µm) on public health is of great concern worldwide. Knowledge on their harmful effects are mainly due to studies carried out with whole air particles, being the contribution of their different fractions largely unknown. Herein, a set of urban PM2.5 samples were collected during day and nighttime periods in Autumn and Spring, aimi...
Oxidized phosphatidylserine mitigates LPS-triggered macrophage inflammatory sta...
Maciel, Elisabete; Neves, Bruno M.; Martins, João; Colombo, Simone; Cruz, Maria Teresa; Domingues, Pedro; Domingues, M. Rosário M.Recent evidence suggests that phosphatidylserine (PS) and its oxidized species drive the clearance of apoptotic cells by macrophages with putative immune response modulation. However, it is not clear whether PS and oxidized PS differentially modulate at molecular level the functional responses of macrophages. Therefore, we proposed in this work to explore this question by evaluating the influence of PS oxidatio...
Polyvinylidene fluoride-Hyaluronic acid wound dressing comprised of ionic liqui...
Abednejad, Atiye; Ghaee, Azadeh; Morais, Eduarda S.; Sharma, Mukesh; Neves, Bruno M.; Freire, Mara G.; Nourmohammadi, Jhamak; Mehrizi, Ali AboueiTo improve the efficacy of transdermal drug delivery systems, the physical and chemical properties of drugs need to be optimized to better penetrate into the stratum corneum and to better diffuse into the epidermis and dermis layers. Accordingly, dual-biological function ionic liquids composed of active pharmaceutical ingredients were synthesized, comprising both analgesic and anti-inflammatory properties, by c...
Enhancing the Antioxidant Characteristics of Phenolic Acids by Their Conversion...
Sintra, Tania E.; Luis, Andreia; Rocha, Samuel N.; Lobo Ferreira, Ana I. M. C.; Goncalves, Fernando; Santos, Luis M. N. B. F.; Neves, Bruno M.Because of the close relation between oxidative stress and a plethora of inflammatory diseases, antioxidants have received an increased attention for incorporation into dermatological products. Their use and absorption are, however, limited by their low solubility in water-rich formulations. Herein, a set of novel cholinium-based salts, namely dicholinium ellagate and cholinium caffeate, syringate, vanillate, g...