19 documents found, page 1 of 2
Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid mem...
Doval Neto,José; Marques,Rodrigo Fernando Costa; Motta,Adriana Cristina; Duek,Eliana Aparecida de Rezende; Oliveira,Guilherme José Pimentel Lopes deThe use of selective barriers as resorbable membranes has become a routine clinical procedure for guided bone regeneration. Therefore, the production of membranes with a low inflammatory potential during their resorption process has become the goal of a considerable number of researches. Aim The purpose of the present study was to evaluate the biocompatibility of poly (L- lactic acid) (PLLA) and biocelulose mem...
In vivo evaluation of porous hydrogel pins to fill osteochondral defects in rab...
Cardoso,Túlio Pereira; Ursolino,André Petry Sandoval; Casagrande,Pamela de Melo; Caetano,Edie Benedito; Mistura,Daniel ViniciusABSTRACT OBJECTIVE: This experimental study aimed to evaluate the biological performance of poly (l-co-D, l-lactic acid)-co-trimetilene carbonate/poly (vinyl alcohol) (PLDLA-co TMC/PVA), hydrogel scaffolds, as an implant in the filling (and not in the repair) of osteochondral defects in New Zealand rabbits, assessing the influence of the material in tissue protection in vivo. METHODS: Twelve rabbits were divide...
In vitro and in vivo cell tracking of PKH26-labeled osteoblasts cultured on PLD...
Duek,Alice Rezende; Costa,Gabriel Ciambelli Dias da; Más,Bruna Antunes; Barbo,Maria Lourdes Peris; Motta,Adriana CristinaAbstract The importance of monitoring in vivo interaction that occurs between cells /bio/tissue recipient in the understanding of tissue regeneration processes becomes ever greater. This study aims to monitor and evaluate the influence of scaffold implants of poly (L-co-D, L lactic acid) - PLDLA synthesized in the laboratory, previously cultured with primary osteoblastic cells heterologously stained with the fl...
Caracterização de pinos da blenda poli(L-co-D,L ácido láctico)/poli(caprolacton...
Duarte,Marcia Adriana Tomaz; Motta,Adriana Cristina; Duek,Eliana Aparecida de RezendeResumo Os dispositivos de fixação óssea, metálicos convencionais, usados em cirurgia crâniomaxilofacial têm apresentado alguns problemas, tais como, corrosão, inflamação e infecção, além de neoformação de estrutura óssea mecanicamente inferior devido à atrofia gerada pela diferença de módulo elástico entre metal e osso, razões que têm levado ao aumento do interesse por dispositivos poliméricos bioarreabsorvívei...
Biological Evaluation of PLDLA Polymer Synthesized as Construct on Bone Tissue ...
Más,Bruna Antunes; Freire,Diego Coutinho de Luna; Cattani,Silvia Mara de Melo; Motta,Adriana Cristina; Barbo,Maria Lourdes PerisIn bone tissue engineering, cell-scaffold constructs are used to stimulate complete, functional tissue replacement that does not occur naturally in critical-size defects. In this report, we describe the application potential of poly (L-co-D,L lactic acid)-PLDLA 70/30, synthesized in house as constructs loaded with osteoblast-like cells on bone tissue engineering. In vitro biological results show that the poroge...
In vitro degradation of poly (L-co-D,L lactic acid) containing PCL-T
Duarte,Marcia Adriana Tomaz; Duek,Eliana Aparecida de Rezende; Motta,Adriana CristinaThe application of polymer-based bioresorbable temporary devices in the medical field grows continuously, and professionals from several areas act to solve problems related to body functions lost due to diseases, accidents or natural wear. Here we study the influence from poly(caprolactonetriol) (PCL-T) on the degeneration process in the copolymer poly(L-co-DL-lactic acid) (PLDLA) membrane, by producing PLDLA/P...
Estudo das células Neuro2A sobre os biomateriais PCL e PLLA
Maturana,Luiz Gabriel; Pierucci,Amauri; Simões,Gustavo Ferreira; Oliveira,Alexandre Leite Rodrigues de; Duek,Eliana Aparecida de RezendeOs biomateriais poli L-ácido lático (PLLA) e o poli caprolactona (PCL) são os polímeros mais estudadas na área dos materiais bioreabsorvíveis. Dentre as suas principais características que contribuem para a interação celular, temos a especificidade química da superfície, elétrica, hidrofobicidade e topografia. Ainda, observa-se o tempo de degradação, porosidade, biocompatibilidade com o tecido biológico, bem co...
Membrana de PLDLA-TMC como protetor na regeneração do tendão calcâneo: Estudo i...
Duek,Julia Rezende; Riquetto,Mayara Lopes; Jesus,Daniel Contri; Sabongi Neto,João José; Barbo,Maria Lourdes Peri; Duek,Eliana Aparecida de RezendeUm dos maiores problemas da cirurgia restauradora dos tendões flexores é evitar a formação de aderências, pois limita seu deslizamento. Assim, é muito desejável que a cicatrização ocorra o mais rápido possível, restaurando a capacidade de deslizamento dos tendões, sem limitações dos movimentos. O objetivo deste trabalho foi analisar a resistência do Tendão calcâneo, utilizando membrana de PLDLA-TMC como proteto...
Surface characterization and osteoblast-like Cells culture on collagen modified...
Más,Bruna Antunes; Cattani,Silvia Mara de Mello; Rangel,Rita de Cássia Cipriano; Ribeiro,Gabrielle de Almeida; Cruz,Nilson Cristino; Leite,Fabio de LimaSurface modification techniques based on the grafting of chemical functional groups and immobilization of bioactive molecules have been used to improve biocompatibility and clinical performance of bioabsorbable scaffolds in tissue engineering and medicine regenerative applications. This study aimed at developing and characterizing a biomimetic surface to stimulate bone regeneration by a simple and low-cost meth...
Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-la...
Motta,Adriana Cristina; Duek,Eliana Aparecida de RezendeTerpolymers of L-lactide, D,L-lactide and trimethylene carbonate (TMC) were synthesized via the ring-opening polymerization reaction for cyclic monomers using stannous octoate as the initiator at a ratio of ~0.05 mol% (monomers/(SnOct)2). Synthesis was done at 130 ºC for 48 h. The inclusion of TMC, an aliphatic elastomeric polycarbonate, alongside polymer chain segments containing L-lactide and D,L-lactide, was...