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IL-17 triggers the onset of cognitive and synaptic deficits in early stages of ...

Cristiano Brigas, Maria Helena; Ribeiro, Miguel; Coelho, Joana E; Gomes, Rui; Gomez-Murcia, Victoria; Carvalho, Kevin; Faivre, Emilie

Neuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has been recognized for decades, but the contribution of the recently described meningeal immune population to AD pathogenesis remains to be addressed. Here, using the 3xTg-AD model, we report an accumulation of interleukin-17 (IL-17)-producing cells, mostly γδ T cells, in the brain and the meninges of female, but not male, mic...

Date: 2021   |   Origin: Repositório da Universidade de Lisboa
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