2 documents found, page 1 of 1
The review of the methods to obtain non-neuronal cells to study glial influence...
Scorisa,Juliana Milani; Duobles,Tatiana; de Oliveira,Gabriela Pintar; Maximino,Jessica Ruivo; Chadi,GersonPURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that displays a rapid evolution. Current treatments have failed to revert clinical symptoms because the mechanisms involved in the death of motoneuron are still unknown. Recent publications have put non-neuronal cells, particularly, astrocyte and microglia, in the scenario of pathophisiology of the disease. Animal models for ALS, ...
S100ß and fibroblast growth factor-2 are present in cultured Schwann cells and ...
Duobles,Tatiana; Lima,Thais de Sousa; Levy,Beatriz de Freitas Azevedo; Chadi,GersonPURPOSE: The neurotrophic factor fibroblast growth factor-2 (FGF-2, bFGF) and Ca++ binding protein S100ß are expressed by the Schwann cells of the peripheral nerves and by the satellite cells of the dorsal root ganglia (DRG). Recent studies have pointed out the importance of the molecules in the paracrine mechanisms related to neuronal maintenance and plasticity of lesioned motor and sensory peripheral neurons....