7 documents found, page 1 of 1
Impact of the physiological stage on the bioaccessibility of α-tocopherol from ...
Fernandes, Jean Michel; Ménard, Olivia; Cochet, Marie-Françoise; Ossemond, Jordane; Vicente, A. A.; Pinheiro, A. C.; Dupont, DidierAge-related physiological decline negatively impacts nutrient digestion and absorption, making older adults more susceptible to diet-related diseases. Fortified and functional foods are promising strategies to enhance the delivery of nutraceuticals and bioactive compounds. However, understanding how these foods behave under age-specific gastrointestinal conditions is essential. Despite the relevance of in vitro...
A Shared Perspective on in Vitro and in Vivo Models to Assay Intestinal Transep...
Hevia, Arancha; Ruas-Madiedo, Patricia; Faria, Miguel Angelo; Petit, Valérie; Alves, Bruna; Alvito, Paula; Arranz, Elena; Bastiaan-Net, ShannaAssessing nutrient bioavailability is complex, as the process involves multiple digestion steps, several cellular environments, and regulatory-metabolic mechanisms. Several in vitro models of different physiological relevance are used to study nutrient absorption, providing significant challenges in data evaluation. However, such in vitro models are needed for mechanistic studies as well as to screen for biolog...
INFOGEST static in vitro simulation of gastrointestinal food digestion
Brodkorb, André; Egger, Lotti; Alminger, Marie; Alvito, Paula; Assunção, Ricardo; Ballance, Simon; Bohn, Torsten; Bourlieu-Lacanal, ClaireDeveloping a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on a...
Extending in vitro digestion models to specific human populations: Perspectives...
Carmit Shani-Levi, Carmit; Alvito, Paula; Andres, Ana; Assunção, Ricardo; Barbera, Reyes; Stephanie, Blanquet-Diot; Dupont, Didier; Martins, CarlaBackground: In vitro digestion models show great promise in facilitating the rationale design of foods. This paper provides a look into the current state of the art and outlines possible future paths for developments of digestion models recreating the diverse physiological conditions of specific groups of the human population. Scope and approach: Based on a collective effort of experts, this paper outlines cons...
Understanding the gastrointestinal tract of the elderly to develop dietary solu...
Rémond, Didier.; Shahar, Danit R.; Gille, Doreen; Pinto, Paula; Kachal, Josefa; Peyron, Marie-Agnès; Santos, Claudia Nunes Dos; Walther, BarbaraAlthough the prevalence of malnutrition in the old age is increasing worldwide a synthetic understanding of the impact of aging on the intake, digestion, and absorption of nutrients is still lacking. This review article aims at filling the gap in knowledge between the functional decline of the aging gastrointestinal tract (GIT) and the consequences of malnutrition on the health status of elderly. Changes in the...
The harmonized INFOGEST in vitro digestion method: From knowledge to action
Egger, Lotti; Menard, Olivia; Delgado-Andrade, Cristina; Alvito, Paula; Assunção, Ricardo; Balance, Simon; Barberá, Reyes; Brodkorb, AndreWithin the active field of in vitro digestion in food research, the COST Action INFOGEST aimed to harmonize in vitro protocols simulating human digestion on the basis of physiologically inferred conditions. A harmonized static in vitro digestion (IVD) method was recently published as a primary output from this network. To validate this protocol, inter-laboratory trials were conducted within the INFOGEST network...
Mycotoxins and applicability of in vitro methods of digestion and absorption as...
Assunção, Ricardo; Ferreira, Mariana; Martins, Carla; Dupont, Didier; Alvito, PaulaMycotoxins are a wide group of fungal secondary metabolites that exert multiple toxic effects on humans and animals1. Patulin, a mycotoxin with significant public health risk, is a toxic secondary metabolite produced by a wide range of fungal species growing on rotten fruit2. In human health risk assessment, ingestion of food is considered a major route of exposure to many contaminants, although the total amoun...