Imported malaria remains a clinical and public health challenge in non-endemic countries. This retrospective study analyzed all adult malaria cases diagnosed at Hospitais da Universidade de Coimbra between 2020 and 2024, and the aim was to characterize the epidemiological profile, assess the impact of previous malaria history, and identify biomarkers associated with disease severity. A total of 88 patients were...
Introduction: The COVID-19 epidemic has been causing serious physical, but also psychological effects in society. This systematic review sought to identify studies that describe COVID-19 related anxiety, and to understand the impact of anxiety assessment in defining strategies to be implemented in future studies.Methodology: This systematic review included cross-sectional studies with no publication year limit....
Molecular Interaction Fields (MIF) is an archetypal computational chemistry technique that can be applied to capture a singular fingerprint of an ensemble of atoms on a protein and encode its physicochemical environment. Thus, MIFs have particular relevance in the context of binding hot spots and binding site analysis. Taking HIV 1 Protease (HIVPR) as case study, the present work focuses on a MIF-based in silic...