12 documents found, page 1 of 2
The adaptive immune landscape of the colorectal adenoma–carcinoma sequence
Freitas, JA; Gullo, I; Garcia, D; Miranda, S; Spaans, L; Pinho, L; Reis, J; Sousa, F; Baptista, M; Resende, C; Leitão, D; Durães, C; Costa, JLBackground. The tumor immune microenvironment exerts a pivotal influence in tumor initiation and progression. The aim of this study was to analyze the immune context of sporadic and familial adenomatous polyposis (FAP) lesions along the colorectal adenoma–carcinoma sequence (ACS). Methods. We analyzed immune cell counts (CD3+, CD4+, CD8+, Foxp3+, and CD57+), tumor mutation burden (TMB), MHC-I expression and PD-...
The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumati...
Castro-Vale, I; Durães, C; van Rossum, EFC; Staufenbiel, SM; Severo, M; Lemos, MC; Carvalho, DPosttraumatic stress disorder (PTSD) has been associated with glucocorticoid (GC) hyper-sensitivity. Although genetic factors account for 30–46% of the variance in PTSD, no associations have been found between single nucleotide polymorphisms (SNPs) of the GC receptor (GR) gene (NR3C1) and risk for this disorder. We studied the association of five SNPs in the GR gene (rs10052957, rs6189/rs6190, rs6195, rs4142324...
Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulatio...
Pereira, MS; Durães, C; Catarino, TA; Costa, JL; Cleynen, I; Novokmet, M; Krištic, J; Štambuk, J; Conceição-Neto, N; Machado, JC; Marcos-Pinto, ROBJECTIVES: The impact of genetic variants (single nucleotide polymorphisms [SNPs]) in the clinical heterogeneity of ulcerative colitis (UC) remains unclear. We showed that patients with UC exhibit a deficiency in MGAT5 glycogene transcription in intestinal T cells associated with a hyperimmune response. Herein, we evaluated whether MGAT5 SNPs might functionally impact on T cells glycosylation and plasma IgG gl...
The influence of the genetic and immunologic context in the development of colo...
Garcia, D; Spaans, L; Miranda, S; Gonçalves, G; Reis, J; Costa, JL; Durães, C; Carneiro, F; Machado, JCIntroduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine whether the hereditary or sporadic context has any influence in the relationship between immune surveillance and tumor d...
The two faces of tumor-associated macrophages and their clinical significance i...
Pinto, ML; Rios, E; Durães, C; Ribeiro, R; Machado, JC; Mantovani, A; Barbosa, MA; Carneiro, F; Oliveira, MJMacrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt different polarization profiles, specifically the pro-inflammatory or M1 and the anti-inflammatory or M2, which display distinct functions. Therefore, concomitantly ...
Differential modulation of cancellous and cortical distal femur by fructose and...
Pereira, C; Guede, D; Durães, C; Brandão, I; Silva, N; Passos, E; Bernardes, M; Monteiro, R; Martins, MJBone mineral density (BMD) and microstructure depend on estrogens and diet. We assessed the impact of natural mineral-rich water ingestion on distal femur of fructose-fed estrogen-deficient female Sprague Dawley rats. Ovariectomized rats drank tap or mineral-rich waters, with or without 10%-fructose, for 10 weeks. A sham-operated group drinking tap water was included (n = 6/group). Cancellous and cortical bone ...
Importance of Cardiac Implantable Eletronic Devices in the Diagnosis of Sleep A...
Ribeiro, S; Bonito, L; Guimarães, MJ; Português, J; Rodrigues, B; Alves, A; Durães, C; Ferreira, D; Sanfins, V; Lourenço, AIntroduction: Sleep Apnea Syndrome (SAS) is a prevalent respiratory disease with marked expression in the population with cardiovascular disease. The diagnosis is based on polysomnography. In patients with cardiac implantable electronic devices (CIED), the prevalence of SAS may reach 60%. The objective of this study was to evaluate the value of DEC in the SAS screening. Methods: Prospective study that included ...
LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis p...
Bernardes, M; Durães, C; Oliveira, A; Martins, MJ; Lucas, R; Costa, L; Pereira, JG; Ramos, I; Machado, JC; Simões-Ventura, FRheumatoid arthritis (RA) is characterized by increased bone resorption and impaired bone formation. Osteoblast function is regulated by the canonical LRP5/Wnt/-catenin pathway. Bone mineral density and RA joint destruction are partially inherited. In line with this, we found significant associations between LRP5 SNPs (p.A1330V, p.N740N, p.V667M) and RA radiographic damage severity.IntroductionIncreased bone re...
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel D...
Pereira, CC; Durães, C; Coelho, R; Grácio, D; Silva, M; Peixoto, A; Lago, P; Pereira, M; Catarino, T; Pinho, S; Teixeira, JP; Macedo, G; Annese, VInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Croh...
Genetic variants in the IL1A gene region contribute to intestinal-type gastric ...
Durães, C; Muñoz, X; Bonet, C; García, N; Venceslá, A; Carneiro, F; Peleteiro, B; Lunet, N; Barros, H; Lindkvist, B; Boutron-Ruault, M-CThe most studied genetic susceptibility factors involved in gastric carcinoma (GC) risk are polymorphisms in the inflammation-linked genes interleukin 1 (IL1) B and IL1RN. Despite the evidence pointing to the IL1 region, definite functional variants reproducible across populations of different genetic background have not been discovered so far. A high density linkage disequilibrium (LD) map of the IL1 gene clus...