6 documents found, page 1 of 1
The Influence of the Genetic and Immunologic Context in the Development of Colo...
Garcia, Diogo; Spaans, Louisa; Miranda, Sara; Gonçalves, Gilza; Reis, Joana; Costa, José Luís; Durães, Cecília; Carneiro, Fátima; Machado, José CarlosIntroduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine whether the hereditary or sporadic context has any influence in the relationship between immune surveillance and tumor d...
The Two Faces of Tumor-Associated Macrophages and Their Clinical Significance i...
Pinto, Marta L.; Rios, Elisabete; Durães, Cecília; Ribeiro, Ricardo; Machado, José C.; Mantovani, Alberto; Barbosa, Mario A.; Carneiro, FátimaMacrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt different polarization profiles, specifically the pro-inflammatory or M1 and the anti-inflammatory or M2, which display distinct functions. Therefore, concomitantly ...
The two faces of tumor-associated macrophages and their clinical significance i...
Pinto, Marta L.; Rios, Elisabete; Durães, Cecília; Ribeiro, Ricardo; Machado, José C.; Mantovani, Alberto; Barbosa, Mário A.; Carneiro, FatimaMacrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt different polarization profiles, specifically the pro-inflammatory or M1 and the anti-inflammatory or M2, which display distinct functions. Therefore, concomitantly ...
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel D...
Costa Pereira, Cristiana; Durães, Cecília; Coelho, Rosa; Grácio, Daniela; Silva, Marco; Peixoto, Armando; Lago, Paula; Pereira, Márcia; Catarino, TelmoInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Croh...
Genetic variants at the Wnt/[beta]-catenin and oestrogen receptor signalling pa...
Amorim, Tânia; Durães, Cecília; Maia, José; Machado, José Carlos; Nogueira, Luísa; Adubeiro, Nuno; Flouris, Andreas D.; Metsios, George S.Research suggests that dancers are at higher risk of developing low bone mineral density (BMD) compared with the general population. However, the associated factors contributing to low BMD in dancers are not fully understood. We aimed to assess the association of single-nucleotide polymorphisms (SNPs) in the Wnt/b-catenin and oestrogen receptor (ER) signalling pathways with low BMD in dancers.
Polymorphisms in the TNFA and IL6 Genes Represent Risk Factors for Autoimmune T...
Durães, Cecília; Moreira, Carla S.; Alvelos, Inês; Mendes, Adélia; Santos, Liliana R.; Machado, José Carlos; Melo, Miguel; Esteves, CésarBackground Autoimmune thyroid disease (AITD) comprises diseases including Hashimoto's thyroiditis and Graves' disease, both characterized by reactivity to autoantigens causing, respectively, inflammatory destruction and autoimmune stimulation of the thyroid-stimulating hormone receptor. AITD is the most common thyroid disease and the leading form of autoimmune disease in women. Cytokines are key regulators of t...