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Portuguese in vitro antibiotic susceptibilities favor current nontuberculous my...
Durão, Vera; Silva, Anabela; Macedo, Rita; Durão, Paulo; Santos-Silva, André; Duarte, RaquelSupplementary material associated with this article can be found in the online version available at doi:10.1016/j.pulmoe.2018.09.001.; Setting: Nontuberculous mycobacteria (NTM) are increasingly recognized as causative agents of opportunistic infections in humans for which effective treatment is challenging. There is, however, very little information on the prevalence of NTM drug resistance in Portugal. Objecti...
Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance
Durão, Paulo; Balbontín, Roberto; Gordo, IsabelThe deposited review is a post-print version and has been submitted to peer review.; This publication hasn't any creative commons license associated.; This deposit is composed by the review, and it hasn't any supplementary materials associated.; The publication deposited was in a state of Epub Ahead of Print, at the time when the upload was made.; Antibiotics target essential cellular functions but bacteria can...
Multidrug-resistant bacteria compensate for the epistasis between resistances
Moura de Sousa, Jorge; Balbontín, Roberto; Durão, Paulo; Gordo, IsabelMutations conferring resistance to antibiotics are typically costly in the absence of the drug, but bacteria can reduce this cost by acquiring compensatory mutations. Thus, the rate of acquisition of compensatory mutations and their effects are key for the maintenance and dissemination of antibiotic resistances. While compensation for single resistances has been extensively studied, compensatory evolution of mu...
Enhanced Survival of Rifampin- and Streptomycin-Resistant Escherichia coli Insi...
Durão, Paulo; Gülereşi, Daniela; Proença, João; Gordo, IsabelThe deposited article is a post-print version and has been submitted to peer review.; This deposit is composed by the main article plus the supplementary materials of the publication.; The evolution of multiple-antibiotic-resistant bacteria is an increasing global problem. Even though mutations causing resistance usually incur a fitness cost in the absence of antibiotics, the magnitude of such costs varies acro...
Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison...
Durão, Paulo; Trindade, Sandra; Sousa, Ana; Gordo, IsabelEvidence is mounting that epistasis is widespread among mutations. The cost of carrying two deleterious mutations, or the advantage of acquiring two beneficial alleles, is typically lower that the sum of their individual effects. Much less is known on epistasis between beneficial and deleterious mutations, even though this is key to the amount of genetic hitchhiking that may occur during evolution. This is part...