9 documents found, page 1 of 1
Diabete tipo 2 e a concentração de hormonas sexuais: macrófagos polarizados nes...
Rocha, A. C.; Soares, R.; Baylina, Pilar; Costa, R.; Alves, M. G.; Fernandes, R.; BAYLINA MACHADO, PILARA testosterona tem diversas funções, destacando-se em cancros hormonodependentes como o cancro da próstata, controlando vias de produção de PSA e estando associado à agressividade tumoral. (1) Doentes diabéticos tipo 2 tendem a apresentar níveis mais baixos de testosterona devido à sua conversão em estradiol no tecido adiposo, geralmente aumentado. (1) Além disso, diabéticos demonstram uma menor incidência para...
Modelo in vitro de polarização de macrófagos modelado pelo shift hormonal em di...
Almeida, C.; Rocha, A. C.; Soares, R.; Baylina, Pilar; Costa, R.; Alves, M. G.; Fernandes, R.; BAYLINA MACHADO, PILARExistem diferentes estímulos que polarizam macrófagos in vitro, estando descritos 2 principais fenótipos: M1 e M2. Entre esses estímulos, o efeito da testosterona e do estradiol neste processo ainda não é totalmente compreendido. Sabe-se que em ambiente diabético existe uma redução da concentração de testosterona e um aumento progressivo de estradiol. As citocinas inflamatórias são respostas produzidas após dif...
A diabetes tipo 2 tem impacto nos níveis de testosterona: Ocorre modelação macr...
Pais, P. J.; Rocha, A. C.; Soares, R.; Baylina, Pilar; Costa, R.; Alves, M. G.; Fernandes, R.; BAYLINA MACHADO, PILARDiversos fatores são capazes de modelar a polarização de macrófagos, incluindo a testosterona e o estradiol, hormonas estas que se encontram diminuídas e aumentadas respetivamente em condição de diabetes. Depois de polarizadas, as células do sistema imunitário libertam fatores que podem ser pró ou anti tumorais.
State interventions to rescue banks during the global financial crisis
Abreu, J. F.; Alves, M. G.; Gulamhussen, M. A.We model unique state interventions to rescue commercial banks during the 2008-09 global financial crisis with the complementary binary logistic model that accommodates their skewed distribution. Our findings show that large and illiquid banks, and banks from countries with weak regulations, and weak shareholder and creditor rights are more likely to receive state interventions. These findings remain robust to ...
Testicular Metabolic Reprogramming in Neonatal Streptozotocin-Induced Type 2 Di...
Rato, L.; Alves, M. G.; Dias, T.; Cavaco, J. E.; Oliveira, Pedro F.Defects in testicular metabolism are directly implicated with male infertility, but most of the mechanisms associated with type 2 diabetes- (T2DM) induced male infertility remain unknown. We aimed to evaluate the effects of T2DM on testicular glucose metabolism by using a neonatal-streptozotocin- (n-STZ) T2DM animal model. Plasma and testicular hormonal levels were evaluated using specific kits. mRNA and protei...
Molecular mechanisms beyond glucose transport in diabetes-related male infertility
Alves, M. G.; Martins, A. D.; Rato, L.; Moreira, P. I.; Socorro, S.; Oliveira, P. F.Diabetes mellitus (DM) is one of the greatest public health threats in modern societies. Although during a few years it was suggested that DM had no significant effect in male reproductive function, this view has been challenged in recent years. The increasing incidence of DM worldwide will inevitably result in a higher prevalence of this pathology in men of reproductive age and subfertility or infertility asso...
Biochemical and metabolic effects of a short-term exposure to nanoparticles of ...
Salvaterra, T.; Alves, M. G.; Domingues, I.; Pereira, R.; Rasteiro, M. G.; Carvalho, R. A.; Soares, A. M. V. M.; Lopes, I.This study aimed to evaluate sublethal effects of a short-term exposure (96h) to titanium silicate nanoparticles (TiSiO4-NP) on Pelophylax perezi tadpoles. Tadpoles were exposed to five concentrations of TiSiO4-NP (8.2, 10.2, 12.8, 16 and 20mg/L) plus a control. Effect criteria were: mortality, cholinesterases, glutathione S-transferases, lactate dehydrogenase, and catalase activities, and alanine and lactate c...
Sperm parameters and epididymis function in transgenic rats overexpressing the ...
Correia, S.; Oliveira, P. F.; Guerreiro, P. M.; Lopes, G.; Alves, M. G.; Canario, Adelino; Cavaco, J. E.; Socorro, SilviaSperm undergo maturation acquiring progressive motility and the ability to fertilize oocytes through exposure to the components of the epididymal fluid (EF). Although the establishment of a calcium (Ca-2) gradient along the epididymis has been described, its direct effects on epididymal function remain poorly explored. Regucalcin (RGN) is a Ca-2-binding protein, regulating the activity of Ca-2-channels and Ca-2...
A model of emotional intelligence and conflict management strategies: a study i...
Rahim, M. A.; Psenicka, C.; Polychroniou, P.; Zhao, J.-H.; Yu, C.-S.; Chan, K. A.; Susana, K. W. S.; Alves, M. G.; Lee, C.-W.; Rahman, S.; Ferdausy, S.The study investigated the relationships of the five dimensions of emotional intelligence: self?awareness, self?regulation, motivation, empathy, and social skills of supervisors to subordinates' strategies of handling conflict: problem solving and bargaining. Data (N = 1,395) for this study were collected with questionnaires from MBA students in seven countries (U.S., Greece, China, Bangladesh, Hong Kong and Ma...