21 documents found, page 1 of 3
Effect of a peptide in cosmetic formulations for hair volume control
Cruz, Célia F.; Ribeiro, Artur J.; Sá, M.; Cavaco-Paulo, ArturObjective The capacity of hair to absorb water causes changes in its physical and cosmetic properties under different environmental conditions. Hence, the control of hair volume in variable relative humidity settings is an important topic in cosmetics. The behaviour of two types of hair, Caucasian and Asian, was studied regarding their volume change in different relative humidity conditions. The ability of a pe...
Cutinase promotes dry esterification of cotton cellulose
Zhao, X.; Matamá, Maria Teresa; Ribeiro, Artur J.; Silva, Carla; Wu, Jing; Fu, Jiajia; Cavaco-Paulo, ArturCutinase from Thermobifida fusca was used to esterify the hydroxyl groups of cellulose with the fatty acids from triolein. Cutinase and triolein were pre-adsorbed on cotton and the reaction proceeded in a dry state during 48 hours at 35ºC. The cutinase-catalyzed esterification of the surface of cotton fabric resulted in the linkage of the oleate groups to the glycoside units of cotton cellulose. The superficial...
Albumin/asparaginase capsules prepared by ultrasound to retain ammonia
Tinoco, Ana Catarina Malheiro; Ribeiro, Artur J.; Oliveira, César João Santos; Parpot, Pier; Gomes, Andreia C; Cavaco-Paulo, Artur"Published online: 17 June 2016"; Asparaginase reduces the levels of asparagine in blood, which is an essential amino acid for the proliferation of lymphoblastic malign cells. Asparaginase converts asparagine into aspartic acid and ammonia. The accumulation of ammonia in the bloodstream leads to hyperammonemia, described as one of the most significant side effects of asparaginase therapy. Therefore, there is a ...
Genetically engineered silk-based composite biomaterials functionalized with fi...
Pereira, Ana Margarida Macedo Bernardes; Machado, Raul; Costa, André Manuel Abreu; Ribeiro, Artur J.; Collins, Tony; Gomes, Andreia C; Leonor, I. B.[Excerpt] Recombinant protein-based polymers (rPBPs) are an emerging class of biopolymers inspired by Nature and produced by synthetic protein biotechnology approaches. Due to their exceptional physical-chemical and biological characteristics, as well as their ability to be customized for specific applications, rPBPs have been explored for the development of advanced biomaterials [1]. Within rPBPs, silk-like po...
BSA/HSA ratio modulates the properties of Ca2+-induced cold gelation scaffolds
Ribeiro, Artur J.; Volkov, Vadim; Oliveira, Mariana Braga; Padrão, Jorge; Mano, J. F.; Gomes, Andreia C; Cavaco-Paulo, Artur"Available online 6 May 2016"; An effective tissue engineering approach requires adjustment according to the target tissue to be engineered. The possibility of obtaining a protein-based formulation for the development of multivalent tunable scaffolds that can be adapted for several types of cells and tissues is explored in this work. The incremental substitution of bovine serum albumin (BSA) by human serum albu...
Ultrasound enhances lipase-catalyzed synthesis of poly (ethylene glutarate)
Xiaoman Zhao; Bansode, Sneha Ramrao; Ribeiro, Artur J.; Abreu, Ana S.; Oliveira, César; Parpot, Pier; Gogate, P. R.; Rathod, V. K.; Paulo, Artur CavacoThe present work explores the best conditions for the enzymatic synthesis of poly (ethylene glutarate) for the first time. The start-up materials are the liquids; diethyl glutarate and ethylene glycol diacetate, without the need of addition of extra solvent. The reactions are catalyzed by lipase B from Candida antarctica immobilized on glycidyl methacrylate-ter-divinylbenzene-ter-ethylene glycol dimethacrylate ...
Improved Poly (D,L-lactide) nanoparticles-based formulation for hair follicle t...
Fernandes, Bruno Pacheco; Silva, R.; Ribeiro, Artur J.; Matamá, Maria Teresa; Gomes, Andreia C; Paulo, Artur CavacoObjective Hair follicles are widely recognized as the preferential target and site of accumulation for nanoparticles after topical application. This feature is of particular importance for hair cosmetics, having the potential to refine the treatment of several hair follicle-related disorders. The aim of this work was to improve the preparation of Poly (D,L-lactide) (PLA) nanoparticles for in vivo follicular tar...
Enzymatic synthesis of poly(catechin)-antibiotic conjugates: an antimicrobial a...
Gonçalves, Idalina; Abreu, Ana S.; Matamá, Maria Teresa; Ribeiro, Artur J.; Gomes, Andreia C; Silva, Carla Manuela Pereira Marinho daBiofilm formation in urinary indwelling catheters is one of the most critical issues that patients face. Catheters were coated with poly(catechin)-antibiotic conjugates with enhanced antimicrobial properties. Catechin was conjugated with two antibiotics, namely trimethoprim (TMP) and sulfamethoxazole (SMZ) via activation with N,N′-disuccinimidyl carbonate (DSC) and subsequent coupling to molecules containing α-...
Synthetic Protein Biotechnology approaches for the creation of antimicrobial bi...
Costa, André Manuel Abreu; Machado, Raul; Ribeiro, Artur J.; Collins, Tony; Thiagarajan, V.; Neves-Petersen, M.T.; Rodríguez-Cabello, J.C.[Excerpt] The spread of antimicrobials resistant microorganisms has triggered the search for new ways to treat infections. In the present work we explored the ABP-CM4 peptide properties from Bombyx mori for the creation of biopolymers with broad antimicrobial activity. An antimicrobial recombinant protein-based polymer (rPBP) was designed by cloning the DNA sequence coding for ABP-CM4 in frame with the N-termin...
Advanced silk-based genetic polymers with improved cell adhesion properties
Pereira, Ana Margarida Macedo Bernardes; Machado, Raul; Bernardo, T.; Costa, André Manuel Abreu; Ribeiro, Artur J.; Collins, Tony; Gomes, Andreia C[Excerpt] Recombinant protein-based polymers (rPBPs) are an emerging class of genetic polymers inspired by Nature and produced by synthetic protein biotechnology approaches. Due to their exceptional physical-chemical and biological characteristics, as well as their ability to be customized for specific applications, rPBPs have been explored for the development of advanced biomaterials [1]. Most of the polymers ...