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Biodegradable seeds of holmium don´t change neurological function after implant...
Diniz, Mirla Fiuza; Ferreira, Diogo Milioli; Lima, Wanderson Geraldo de; Pedrosa, Maria Lúcia; Silva, Marcelo Eustáquio; Araujo, Stanley de AlmeidaAim: To evaluate the surgical procedure and parenchymal abnormalities related to implan-tation of ceramic seeds with holmium-165 in rats’ brain.Background: An effective method of cancer treatment is brachytherapy in which radioactiveseeds are implanted in the tumor, generating a high local dose of ionizing radiation thatcan eliminate tumor cells while protecting the surrounding healthy tissue. BiodegradableHo16...
Oxidative effects on lung inflammatory response in rats exposed to different co...
Murta, Giselle Luciane; Campos, Keila Karine Duarte; Bandeira, Ana Carla Balthar; Diniz, Mirla Fiuza; Costa, Guilherme de Paula; Costa, Daniela CaldeiraThe formaldehyde (FA) is a crosslinking agent that reacts with cellular macromolecules such as proteins, nucleic acids and molecules with low molecular weight such as amino acids, and it has been linked to inflammatory processes and oxidative stress. This study aimed to analyze the oxidative effects on pulmonary inflammatory response in Fischer rats exposed to different concentrations of FA. Twenty-eight Fische...
Analysis of liver fragment subjected to autologous transplant at rat’s retroper...
Diniz, Mirla Fiuza; Siqueira, Sávio Lana; Baumfeld, Tiago Soares; Pereira, Luis Felipe Cintra; Moreira, Filipe Garcia; Ribeiro, Gustavo MeirellesBackground: To investigate the regeneration process of autologous implants of liver on the retroperitoneum. Methods: Thirty male Fisher rats were used divided in to group 1 (G1): studied 60 d after surgery; group 2 (G2): studied 90 d after surgery; group 3 (G3): studied 180 d after surgery; and group C (GC): animals without surgery. Hepatic fragment was processed for histologic and biochemical analysis. Results...
Protótipo de ventilação mecânica espontânea e artificial.
Nagato, Akinori Cardozo; Diniz, Mirla Fiuza; Bandeira, Ana Carla Balthar; Bezerra, Frank SilvaA ventilação mecânica é utilizada como alternativa quando pacientes se encontram em quadros de insuficiência respiratória aguda ou crônica. O presente estudo teve como objetivo apresentar um protótipo que contribuirá para o ensino da ventilação mecânica espontânea e artificial nos cursos das áreas de saúde e biotecnológica. Materiais e Métodos: a pesquisa foi realizada no Laboratório de Biomorfologia e Patologi...
Salt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 ac...
Dornas, Waleska Claudia Amaral; Lima, Wanderson Geraldo de; Santos, Rinaldo Cardoso dos; Souza, Melina Oliveira de; Silva, Maísa; Diniz, Mirla FiuzaParaoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially divided into two groups. Control (CON), which received a normal salt diet and drinking water throu...
High dietary salt decreases antioxidant defenses in the liver of fructose-fed i...
Dornas, Waleska Claudia Amaral; Lima, Wanderson Geraldo de; Santos, Rinaldo Cardoso dos; Guerra, Joyce Ferreira da Costa; Souza, Melina Oliveira deIn this study we investigated the hypothesis that a high-salt diet to hyperinsulinemic rats might impair antioxidant defense owing to its involvement in the activation of sodium reabsorption to lead to higher oxidative stress. Rats were fed a standard (CON), a high-salt (HS), or a high-fructose (HF) diet for 10 weeks after which, 50% of the animals belonging to the HF group were switched to a regimen of high-fr...
Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction ...
Ávila, Danielle de Lima; Araújo, Glaucy Rodrigues de; Silva, Maísa; Miranda, Pedro Henrique de Amorim; Diniz, Mirla Fiuza; Pedrosa, Maria LúciaBackground and Aims. It is believed that oxidative stress plays a role in the pathogenesis of diabetes mellitus. Several strategies have been developed with the objective of minimizing diabetic complications. Among these, inhibitors of dipeptidyl peptidase-IV (DPP-IV), which act by blocking degradation of incretin hormones, glucagon-like peptide hormone (GLP-1) and glucose-dependent insulinotropic polypeptide (...