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Low-dose combination of alendronate and atorvastatin reduces ligature-induced a...
Dutra, Paula Goes Pinheiro; Melo, Iracema Matos; Silva, Luana Maria Castelo Melo; Benevides, Norma Maria Barros; Alencar, Nylane Maria Nunes deMaterial and Methods: Periodontitis was induced by ligature in 78 Wistar rats. Groups of six rats prophylactically received 0.9% saline (SAL), ALD (0.01 or 0.25 mg/kg subcutaneously) or ATV (0.3 or 27 mg/kg by gavage). Then, groups of six rats received the combination of ALD+ATV (0.25 mg/kg + 27 mg/kg, 0.01 mg/ kg + 0.3 mg/kg, 0.25 mg/kg + 0.3 mg/kg or 0.01 mg/kg + 27 mg/kg) prophylactically. An extra group of ...
Date: 2015
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Origin: Oasisbr