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The peptide secreted at the water to land transition in a model amphibian has a...

Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Silva-Carvalho, Amandda É.; Cabral, Wanessa F.

Made available in DSpace on 2022-04-29T08:36:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the develo...

Date: 2022   |   Origin: Oasisbr

The peptide secreted at the water to land transition in a model amphibian has a...

Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Carvalho, Amandda É. Silva; Cabral, Wanessa F.

In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the developmental stage that precedes the onset of terrestrial behaviour. De novo peptide and cDNA sequencing revealed t...

Date: 2022   |   Origin: Oasisbr

Neuroprotective effects on microglia and insights into the structure–activity r...

Plácido, Alexandra; Amaral, Constança Pais Do; Teixeira, Cátia; Nogueira, Ariane; Brango‐Vanegas, José; Alves Barbosa, Eder; C. Moreira, Daniel

Tryptophyllins constitute a heterogeneous group of peptides that are one of the first classes of peptides identified from amphibian's skin secretions. Here, we report the structural characterization and antioxidant properties of a novel tryptophyllin-like peptide, named PpT-2, isolated from the Iberian green frog Pelophylax perezi. The skin secretion of P. perezi was obtained by electrical stimulation and fract...


Neuroprotective effects on microglia and insights into the structure–activity r...

Plácido, Alexandra; Amaral, Constança do Pais do; Teixeira, Cátia; Nogueira, Ariane; Brango-Vanegas, José; Barbosa, Eder Alves; Moreira, Daniel C.

Tryptophyllins constitute a heterogeneous group of peptides that are one of the first classes of peptides identified from amphibian’s skin secretions. Here, we report the structural characterization and antioxidant properties of a novel tryptophyllin-like peptide, named PpT-2, isolated from the Iberian green frog Pelophylax perezi. The skin secretion of P. perezi was obtained by electrical stimulation and fract...


Antibacterial, antibiofilm and cytotoxic activities of Terminalia fagifolia Mar...

Araujo, Alyne Rodrigues de; Quelemes, Patrick Veras; Perfeito, Márcia Luana Gomes; Lima, Luiza Ianny de; Sá, Melka Coêlho; Nunes, Paulo Humberto Moreira

Background: The methicillin resistance of bacteria from the genus Staphylococcus and its ability to form biofilms are important factors in pathogenesis of these microorganisms. Thus, the search for new antimicrobials agents, especially from plants, has been intensified. In this context, Terminalia species have been the subject of research for many pharmacological activities. In this study we evaluated the antib...

Date: 2021   |   Origin: Oasisbr

Effect of saccharomycin, a natural Saccharomyces cerevisiae biocide, on Hanseni...

Calvário, Joana; Silva, Nelly; Almeida, M. Gabriela; Albergaria, Helena; Eaton, Peter; Macedo, Anjos; Caldeira, Jorge


Acetylated cashew-gum-based silver nanoparticles for the development of latent ...

Brandão, Marcela de S.; Jesus, Joilson R.; de Araújo, Alyne R.; de Carvalho, Juarez G.; Peixoto, Miguel; Plácido, Alexandra; Eaton, Peter

Made available in DSpace on 2021-06-25T10:44:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Universidade Estadual Paulista; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fingerprints have been used in forensic investigations as a powerful tool for human identification. However, it is desirable to find new sustainable sources and synthesis for fingerprint developers, in ...

Date: 2021   |   Origin: Oasisbr

Effect of saccharomycin, a natural Saccharomyces cerevisiae biocide, on Hanseni...

Calvário, Joana; Silva, Nelly; Almeida, M. Gabriela; Albergaria, Helena; Eaton, Peter; Macedo, Anjos L.; Caldeira, Jorge

ABSTRACT: During spontaneous wine fermentations, most of the non-Saccharomyces yeasts present in grape musts show an early decline in their population. It was traditionally assumed that Saccharomyces cerevisiae (S.c.) prevalence was due to the higher resistance of this species to ethanol. However, wine fermentations performed with single cultures of non-Saccharomyces strains showed that those strains could with...

Date: 2021   |   Origin: Repositório do LNEG

Mechanistic insights into the leishmanicidal and bactericidal activities of Bat...

Dematei, Anderson; Nunes, João B.; Moreira, Daniel C.; Jesus, Jéssica A.; Laurenti, Márcia D.; Mengarda, Ana C. A.; Vieira, Maria Silva

Snake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are produced by a variety of organisms. Batroxicidin (BatxC) is a cathelicidin found in the venom of the common lancehead (Bothrops atrox). In the present work, BatxC and two synthetic analogues, BatxC(C-2.15Phe) and BatxC(C-2.14Phe)des-Phe1, were assessed f...


The antioxidant peptide salamandrin-i: First bioactive peptide identified from ...

Plácido, Alexandra; Bueno, João; Barbosa, Eder A.; Moreira, Daniel C.; Dias, Jhones Do Nascimento; Cabral, Wanessa Felix; Albuquerque, Patrícia

Made available in DSpace on 2020-12-12T02:01:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01; Universidade Estadual Paulista; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação para a Ciência e a Tecnologia; Amphibian skin is a multifunctional organ that plays key roles in defense, breathing, and wat...

Date: 2020   |   Origin: Oasisbr

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