2 documents found, page 1 of 1
The Trypanosoma cruzi virulence factor Oligopeptidase B (OPBTc) assembles into ...
Motta, Flávia da Silva Nader; Bastos, Izabela Marques Dourado; Faudry, Eric; Ebel, Christine; Lima, Meire Maria de; Neves, David; Ragno, MichelOligopeptidase B, a processing enzyme of the prolyl oligopeptidase family, is considered as an important virulence factor intrypanosomiasis. Trypanosoma cruzi oligopeptidase B (OPBTc) is involved in host cell invasion by generating a Ca2+-agonist necessary for recruitment and fusion of host lysosomes at the site of parasite attachment. The underlying mechanism remains unknown and further structural and function...
The major leucyl aminopeptidase of Trypanosoma cruzi (LAPTc) assembles into a h...
Cadavid-Restrepo, Gloria Ester; Gastardelo, Thiago Santana; Faudry, Eric; Silva, Hugo de Almeida; Bastos, Izabela Marques DouradoBackground Pathogens depend on peptidase activities to accomplish many physiological processes, including interaction with their hosts, highlighting parasitic peptidases as potential drug targets. In this study, a major leucyl aminopeptidolytic activity was identified in Trypanosoma cruzi, the aetiological agent of Chagas disease. Results The enzyme was isolated from epimastigote forms of the parasite by a two-...