9 documents found, page 1 of 1
In vitro study of Hesperetin and Hesperidin as inhibitors of zika and chikungun...
Eberle, Raphael J. [UNESP]; Olivier, Danilo S.; Pacca, Carolina C. [UNESP]; Avilla, Clarita M.S. [UNESP]; Nogueira, Mauricio L.; Amaral, Marcos S.Made available in DSpace on 2021-06-25T10:55:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01; National Institute of Biological Resources; The potential outcome of flavivirus and alphavirus co-infections is worrisome due to the development of severe diseases. Hundreds of millions of people worldwide live under the risk of infections caused by viruses like chikungunya virus (CHIKV, genus Alphaviru...
Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molec...
Loschwitz, Jennifer; Jäckering, Anna; Keutmann, Monika; Olagunju, Maryam; Eberle, Raphael J. [UNESP]; Coronado, Monika Aparecida; Olubiyi, Olujide O.Made available in DSpace on 2021-06-25T10:27:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-01; For the COVID-19 pandemic caused by SARS-CoV-2, there are currently no effective drugs or vaccines to treat this coronavirus infection. In this study, we focus on the main protease enzyme of SARS-CoV-2, 3CLpro, which is critical for viral replication. We employ explicit solvent molecular dynamics simula...
A comparative pan-genomic analysis of 53 C. pseudotuberculosis strains based on...
Bernardes, Juliana S.; Eberle, Raphael J. [UNESP]; Vieira, Fabio R. J.; Coronado, Mônika A. [UNESP]Made available in DSpace on 2020-12-12T02:18:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Corynebacterium pseudotuberculosis is a pathogenic bacterium with great veterinary and economic importance. It is classified into two biovars: ovis, nitrate-negative, that causes lymphadenitis in small ruminants and equi, nitrate-positive, causing ulcerative lymphangitis in equines. With the explosive g...
The polyanions heparin and suramin impede binding of free adenine to a DNA glyc...
Eberle, Raphael J. [UNESP]; Coronado, Monika A. [UNESP]; Peinado, Rafaela S. [UNESP]; de Moraes, Fabio R. [UNESP]; Olivier, Danilo [UNESP]Made available in DSpace on 2019-10-06T16:09:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-03-15; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Currently no effective treatment is available to combat infections caused by Corynebacterium pseudotub...
Binding studies of a putative C. pseudotuberculosis target protein from Vitamin...
Peinado, Rafaela Dos S [UNESP]; Olivier, Danilo S. [UNESP]; Eberle, Raphael J. [UNESP]; de Moraes, Fabio R. [UNESP]; Amaral, Marcos S.Made available in DSpace on 2019-10-06T16:29:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-04-23; Vitamin B12 acts as a cofactor for various metabolic reactions important in living organisms. The Vitamin B12 biosynthesis is restricted to prokaryotes, which means, all eukaryotic organisms must acquire this molecule through diet. This study presents the investigation of Vitamin B12 metabolism and the ...
Putative virulence factors of Corynebacterium pseudotuberculosis FRC41: vaccine...
Santana-Jorge, Karina T. O.; Santos, Tulio M.; Tartaglia, Natayme R.; Aguiar, Edgar L.; Souza, Renata F. S.; Mariutti, Ricardo B. [UNESP]Made available in DSpace on 2018-11-26T15:29:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-05-16; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); FAPESB; Background: Corynebacterium pseudotuberculosis, a facultative intracellular bacterial path...
Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus...
Drebes, Julia; Künz, Madeleine; Windshügel, Björn; Kikhney, Alexey G.; Müller, Ingrid B.; Eberle, Raphael J. [UNESP]; Oberthür, Dominik; Cang, HuaixingMade available in DSpace on 2018-12-11T16:41:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-03-10; Bundesministerium für Bildung und Forschung; Infections caused by the methicillin-resistant Staphylococcus aureus (MRSA) are today known to be a substantial threat for global health. Emerging multi-drug resistant bacteria have created a substantial need to identify and discover new drug targets and to d...
Inhibition of thioredoxin A1 from Corynebacterium pseudotuberculosis by polyani...
Eberle, Raphael J. [UNESP]; Kawai, Liege A. [UNESP]; de Moraes, Fabio R. [UNESP]; Olivier, Danilo [UNESP]; do Amaral, Marcos S.; Tasic, LjubicaMade available in DSpace on 2018-12-11T17:20:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-10-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul; ...
Biochemical and biophysical characterization of a mycoredoxin protein glutaredo...
Eberle, Raphael J. [UNESP]; Kawai, Liege A. [UNESP]; de Moraes, Fabio R. [UNESP]; Tasic, Ljubica; Arni, Raghuvir K. [UNESP]; Coronado, Monika A. [UNESP]Made available in DSpace on 2018-12-11T17:15:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-02-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Glutaredoxin A1 from Corynebacterium pseudotuberculosis was shown to be a mycoredoxin protein. In this...