6 documents found, page 1 of 1

Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ...

Indole alkaloids ellipticine (1), cryptolepine triflate (2a), rationally designed 11-(4-piperidinamino)cryptolepine hydrogen dichloride (2b) and olivacine (3) (an isomer of 1) were evaluated in vitro against Plasmodium falciparum and in vivo in Plasmodium berghei-infected mice. 1-3 inhibited P. falciparum (IC50 ≤ 1.4 μM, order of activity: 2b > 1 > 2a > 3). In vitro toxicity to murine macrophages was evaluated ...

In vitro and in vivo anti-malarial activity of limonoids isolated from the resi...

Background: Carapa guianensis is a cultivable tree used by traditional health practitioners in the Amazon region to treat several diseases and particularly symptoms related to malaria. Abundant residual pressed seed material (RPSM) results as a by-product of carapa or andiroba oil production. The objective of this study was to evaluate the in vitro and in vivo anti-malarial activity and cytotoxicity of limonoid...

Electrophoresis and spectrometric analyses of adaptation-related proteins in th...

Chromobacterium violaceum is a Gram-negative proteobacteria found in water and soil; it is widely distributed in tropical and subtropical regions, such as the Amazon rainforest. We examined protein expression changes that occur in C. violaceum at different growth temperatures using electrophoresis and mass spectrometry. The total number of spots detected was 1985; the number ranged from 99 to 380 in each assay....

Lipid profiles of follicular fluid from cows submitted to ovarian superstimulation

Made available in DSpace on 2018-11-26T17:29:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-05-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Ovarian superstimulation with exogenous gonadotropins has been extensively used to produce in vivo derived embryos for embryo transfer in cattle. This process modifies the antral follicle microenvironment and affects oocyte and embryo qualit...

Influence of spermatozoal lipidomic profile on the cryoresistance of frozen spe...

Made available in DSpace on 2018-12-11T17:16:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-03-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The membrane of spermatozoa, which contributes to cellular cryoresistance, contains numerous lipids with a composition that directly affects membrane fluidity and the ferti...

Desorption electrospray ionization mass spectrometry imaging reveals chemical d...