12 documents found, page 1 of 2
Rates of adverse events in patients with Ulcerative Colitis undergoing colectom...
Dragoni, Gabriele; Innocenti, Tommaso; Amiot, Aurelién; Castiglione, Fabiana; Melotti, Laura; Festa, Stefano; Savarino, Edoardo Vincenzo; Truyens, MarieINTRODUCTION: Patients with ulcerative colitis (UC) receiving immunosuppressive drugs are at substantial risk of colectomy. We aimed to assess the risk of postoperative complications of tofacitinib exposure before colectomy in comparison with biologics. METHODS: A multicenter, retrospective, observational study was conducted in patients with UC who underwent total colectomy for medically refractory disease, exp...
Hydrogels for modified-release drug delivery systems
Zielinska, Aleksandra; Eder, Piotr; Rannier, Lucas; Cardoso, Juliana C.; Severino, Patrícia; Silva, Amélia M.; Souto, Eliana Maria BarbosaHydrogels for the modified-release drug delivery systems is a continuously growing area of interest for the pharmaceutical industry. According to the global market, the use of polymers in this area is projected to reach $31.4 million by 2027. This review discusses the recent advances and perspectives of hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic. The search strategy d...
Cancer Nanopharmaceuticals: Physicochemical Characterization and In Vitro/In Vi...
Zielińska, Aleksandra; Szalata, Marlena; Gorczyński, Adam; Karczewski, Jacek; Eder, Piotr; Severino, Patrícia; Cabeda, José M.; Souto, Eliana B.Physicochemical, pharmacokinetic, and biopharmaceutical characterization tools play a key role in the assessment of nanopharmaceuticals' potential imaging analysis and for site-specific delivery of anti-cancers to neoplastic cells/tissues. If diagnostic tools and therapeutic approaches are combined in one single nanoparticle, a new platform called nanotheragnostics is generated. Several analytical technologies ...
Cancer nanopharmaceuticals: physicochemical characterization and in vitro/in vi...
Zielińska, Aleksandra; Szalata, Marlena; Gorczyński, Adam; Karczewski, Jacek; Eder, Piotr; Severino, Patrícia; Cabeda, JM; Souto, Eliana B.Physicochemical, pharmacokinetic, and biopharmaceutical characterization tools play a key role in the assessment of nanopharmaceuticals’ potential imaging analysis and for site-specific delivery of anti-cancers to neoplastic cells/tissues. If diagnostic tools and therapeutic approaches are combined in one single nanoparticle, a new platform called nanotheragnostics is generated. Several analytical technologies ...
How could nanobiotechnology improve treatment outcomes of anti-TNF-α therapy in...
Eder, Piotr; Zielinska, Aleksandra; Karczewski, Jacek; Dobrowolska, Agnieszka; Slomski, Ryszard; Souto, Eliana B.Despite significant advances in therapeutic possibilities for the treatment of inflammatory bowel disease (IBD) in recent years, there is still a big room for improvement. In particular, biological treatment can induce not only clinical remission but also mucosal healing of the gastrointestinal tract. Among these therapeutic molecules, anti-tumor necrosis factor-alpha (anti-TNF-$\alpha$) antibodies were the fir...
Two- and Three-Dimensional Spectrofluorimetric Qualitative Analysis of Selected...
Zielińska, Aleksandra; Kubasiewicz, Konrad; Wójcicki, Krzysztof; Silva, Amélia M.; Nunes, Fernando M.; Szalata, Marlena; Słomski, Ryszard; Eder, PiotrVegetable oils obtained from different plants are known for their beneficial effects on prophylaxis and supportive treatment of a great deal of inflammatory-mediated conditions. Their wide range of saturated and unsaturated fatty acids, and the presence of other ingredients (e.g., tocopherols, chlorophylls), provide them with anti-inflammatory, antioxidant and anticancer properties, which are worth being exploi...
Polymeric nanoparticles: production, characterization, toxicology and ecotoxico...
Zielinska, Aleksandra; Carreiró, Filipa; Oliveira, Ana M.; Neves, Andreia; Pires, Bárbara; Venkatesh, D. Nagasamy; Durazzo, AlessandraPolymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several d...
Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance
Zielinska, Aleksandra; Costa, Beatriz; Ferreira, Maria V.; Miguéis, Diogo; Louros, Jéssica M. S.; Durazzo, Alessandra; Lucarini, Massimo; Eder, PiotrThis review offers a systematic discussion about nanotoxicology and nanosafety associated with nanomaterials during manufacture and further biomedical applications. A detailed introduction on nanomaterials and their most frequently uses, followed by the critical risk aspects related to regulatory uses and commercialization, is provided. Moreover, the impact of nanotoxicology in research over the last decades is...
Properties, extraction methods, and delivery systems for curcumin as a natural ...
Zielinska, Aleksandra; Alves, Henrique; Marques, Vánia; Durazzo, Alessandra; Lucarini, Massimo; Alves, Thais F.; Morsink, Margreet; Willemen, NielsThis review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome the...
Is the retinol-binding protein 4 a possible risk factor for cardiovascular dise...
Rychter, Anna Maria; Skrzypczak-Zielinska, Marzena; Zielinska, Aleksandra; Eder, Piotr; Souto, Eliana B.; Zawada, Agnieszka; Ratajczak, Alicja EwaAlthough many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity...