2 documents found, page 1 of 1
MLL leukemia-associated rearrangements in peripheral blood lymphocytes from hea...
Brassesco,María Sol; Montaldi,Ana Paula; Gras,Diana Ester; Queiroz,Rosane Gomes de Paula; Martinez-Rossi,Nilce Maria; Tone,Luiz GonzagaChromosomal translocations are characteristic of hematopoietic neoplasias and can lead to unregulated oncogene expression or the fusion of genes to yield novel functions. In recent years, different lymphoma/leukemia-associated rearrangements have been detected in healthy individuals. In this study, we used inverse PCR to screen peripheral lymphocytes from 100 healthy individuals for the presence of MLL (Mixed L...
Multiple drug resistance protein (MDR-1), multidrug resistance-related protein ...
Valera,Elvis Terci; Scrideli,Carlos Alberto; Queiroz,Rosane Gomes de Paula; Mori,Bianca Maria Ortelli; Tone,Luiz GonzagaCONTEXT: Despite the advances in the cure rate for acute lymphoblastic leukemia, approximately 25% of affected children suffer relapses. Expression of genes for the multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP), and lung resistance protein (LRP) may confer the phenotype of resistance to the treatment of neoplasias. OBJECTIVE: To analyze the expression of the MDR-1, MRP and...