3 documents found, page 1 of 1
New insights into the role of histamine in subventricular zone-olfactory bulb n...
Eiriz, Maria F.; Valero, Jorge; Malva, João O.; Bernardino, LilianaThe subventricular zone (SVZ) contains neural stem cells (NSCs) that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the identification of proneurogenic factors crucial for stem cell-based therapies will have an impact ...
Expression variability of co-regulated genes differentiates Saccharomyces cerev...
Carreto, Laura; Eiriz, Maria F.; Domingues, Inês; Schuller, Dorit; Moura, Gabriela R.; Santos, Manuel A. S.Background: Saccharomyces cerevisiae (Baker’s yeast) is found in diverse ecological niches and is characterized by high adaptive potential under challenging environments. In spite of recent advances on the study of yeast genome diversity, little is known about the underlying gene expression plasticity. In order to shed new light onto this biological question, we have compared transcriptome profiles of five envi...
Comparative genomics of wild type yeast strains unveils important genome diversity
Carreto, Laura; Eiriz, Maria F.; Gomes, Ana C.; Pereira, Patrícia M; Schuller, Dorit Elisabeth; Santos, Manuel A. S.Genome variability generates phenotypic heterogeneity and is of relevance for adaptation to environmental change, but the extent of such variability in natural populations is still poorly understood. For example, selected Saccharomyces cerevisiae strains are variable at the ploidy level, have gene amplifications, changes in chromosome copy number, and gross chromosomal rearrangements. This suggests that genome ...