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European Headache Federation (EHF) critical re-appraisal and meta-analysis of o...

Deligianni, Christina I.; Sacco, Simona; Ekizoglu, Esme; Uluduz, Derya; Gil-Gouveia, Raquel; MaassenVanDenBrink, Antoinette; Ornello, Raffaele

Objective: Novel disease-specific and mechanism-based treatments sharing good evidence of efficacy for migraine have been recently marketed. However, reimbursement by insurers depends on treatment failure with classic anti-migraine drugs. In this systematic review and meta-analysis, we aimed to identify and rate the evidence for efficacy of flunarizine, a repurposed, first- or second-line treatment for migraine...


Acute symptomatic seizures in cerebral venous thrombosis

Lindgren, Erik; Silvis, Suzanne M.; Hiltunen, Sini; Heldner, Mirjam R.; Serrano, Fabiola; de Scisco, Michele; Zelano, Johan; Zuurbier, Susanna M.

Objective: To identify characteristics, predictors, and outcomes of acute symptomatic seizures (ASS) in cerebral venous thrombosis (CVT), we investigated 1,281 consecutive adult patients with CVT included from 12 hospitals within the International CVT Consortium. Methods: We defined ASS as any seizure between symptom onset and 7 days after diagnosis of CVT. We stratified ASS into prediagnosis and solely postdia...


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