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Health-related quality of life at 5 years of age for children born very preterm...

Kim, SW; Tian, X; Andronis, L; Maier, RF; Varendi, H; Seppänen, A-V; Siljehav, V; Draper, ES; Zeitlin, J; Petrou, S; Seppänen, AV; El Rafei, R

Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares...


Motor-related health care for 5-year-old children born extremely preterm with m...

Costa, R; Aubert, AM; Seppänen, A-V; Ådén, U; Sarrechia, L; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Johnson, S

Aim: To (1) determine the proportion of 5-year-old children born extremely preterm (EPT) with movement difficulties including cerebral palsy (CP) and the proportion of these children receiving motor-related health care (MRHC), and (2) describe factors associated with receiving MRHC. Method: Children born before 28 weeks’ gestation in 2011 to 2012 in 11 European countries were assessed with the Movement Assessme...


Variation in very preterm extrauterine growth in a European multicountry cohort

El Rafei, R; Jarreau, PH; Norman, M; Maier, RF; Barros, H; Reempts, PV; Pedersen, P; Cuttini, M; Zeitlin, J; EPICE Research Group

Objective Extrauterine growth restriction (EUGR) among very preterm infants is related to poor neurodevelopment, but lack of consensus on EUGR measurement constrains international research. Our aim was to compare EUGR prevalence in a European very preterm cohort using commonly used measures. Design Population-based observational study. Setting 19 regions in 11 European countries. Patients 6792 very preterm infa...


Parents' ratings of post-discharge healthcare for their children born very pret...

Seppänen, AV; Sauvegrain, P; Draper, ES; Toome, L; El Rafei, R; Petrou, S; Barros, H; Zimmermann, LJI; Cuttini, M; Zeitlin, J; SHIPS Research Group

Background Follow-up of very preterm infants is essential for reducing risks of health and developmental problems and relies on parental engagement. We investigated parents’ perceptions of post-discharge healthcare for their children born very preterm in a European multi-country cohort study. Methods Data come from a 5-year follow-up of an area-based cohort of births <32 weeks’ gestation in 19 regions from 11 E...


Association between postnatal growth and neurodevelopmental impairment by sex a...

El Rafei, R; Jarreau, PH; Norman, M; Maier, RF; Barros, H; Van Reempts, P; Pedersen, P; Cuttini, M; Costa, R; Zemlin, M; Draper, ES; Zeitlin, J

Background & aims: Extra-uterine growth restriction (EUGR) is common among very preterm (VPT) infants and has been associated with impaired neurodevelopment. Some research suggests that adverse effects of EUGR may be more severe in boys. We investigated EUGR and neurodevelopment at 2 years of corrected age (CA) by sex in a VPT birth cohort. Methods: Data come from a population-based cohort of children born <32 ...


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