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Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes:...

Fernandes, A; Avraam, D; Cadman, T; Dadvand, P; Guxens, M; Binter, A-C; Pinot de Moira, A; Nieuwenhuijsen, M; Duijts, L; Julvez, J; De Castro, M

Studies evaluating the benefits and risks of green spaces on children's health are scarce. The present study aimed to examine the associations between exposure to green spaces during pregnancy and early childhood with respiratory, cardiometabolic, and neurodevelopmental outcomes in school-age children. We performed an Individual-Participant Data (IPD) meta-analysis involving 35,000 children from ten European bi...


Parental infertility and offspring cardiometabolic trajectories: a pooled analy...

Hernáez, Á; Elhakeem, A; Barros, H; Vrijkotte, TGM; Fraser, A; Lawlor, DA; Magnus, MC

Objective To assess whether parental infertility is associated with differences in cardiometabolic trajectories in offspring. Design Pooled observational analysis in three prospective cohorts. Setting Three nationwide pregnancy cohorts. Patients A total of 14,609 singletons from the UK Avon Longitudinal Study of Parents and Children, the Portuguese Geraçao 21, and the Amsterdam Born Children and Their Developme...


Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Ea...

Gonçalves Soares, A; Santos, S; Seyve, E; Nedelec, R; Puhakka, S; Eloranta, A-M; Mikkonen, S; Yuan, WL; Lawlor, DA; Heron, J; Vrijheid, M; Lepeule, J

Background: Prenatal urban environmental exposures have been associated with blood pressure in children. The dynamic of these associations across childhood and later ages is unknown. Objectives: The purpose of this study was to assess associations of prenatal urban environmental exposures with blood pressure trajectories from childhood to early adulthood. Methods: Repeated measures of systolic blood pressure (S...


Long-term cardiometabolic health in people born after assisted reproductive tec...

Elhakeem, A; Taylor, AE; Inskip, HM; Huang, JY; Mansell, T; Rodrigues, C; Asta, F; Blaauwendraad, SM; Haberg, SE; Halliday, J; Harskamp-van Ginkel, MW

Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 popu...


Gestational age at birth and body size from infancy through adolescence: An ind...

Vinther, JL; Cadman, T; Avraam, D; Ekstrom, CT; Sorensen, TIA; Elhakeem, A; Santos, AC; de Moira, AP; Heude, B; Iñiguez, C; Pizzi, C; Simons, E

Background Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as a proxy of prematurity rather than an actual length of gestation. ...


Exposure to natural environments during pregnancy and birth outcomes in 11 euro...

Torres Toda, M; Avraam, D; James Cadman, T; Fossati, S; de Castro, M; Dedele, A; Donovan, G; Elhakeem, A; Estarlich, M; Fernandes, A; Gonçalves, R

Research suggests that maternal exposure to natural environments (i.e., green and blue spaces) promotes healthy fetal growth. However, the available evidence is heterogeneous across regions, with very few studies on the effects of blue spaces. This study evaluated associations between maternal exposure to natural environments and birth outcomes in 11 birth cohorts across nine European countries. This study, par...


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