7 documents found, page 1 of 1
Double-blind clinical trial of arginine supplementation in the treatment of adu...
Eleutério, Renata Mirian Nunes; Nascimento, Francisco O.; Araújo, Tamara G.; Castro, Marilena F.; Almeida Filho, Tarcísio Paulo de; Maia Filho, Pedro A.Background. Sickle cell anaemia (SCA) is the most prevalentmonogenic disease in Brazil. In SCA, haemoglobin S (HbS) is formed, whichmodifies red blood cell morphology. Intravascular haemolysis occurs, in which free Hb and free radicals degrade nitric oxide (NO) and release arginase, which reduces arginine levels. Because arginine is a substrate for NO formation, this decrease leads to reduced NO (vasodilator) s...
Antiretroviral changes during the first year of therapy
Bandeira, Antonio Carlos Policarpo Carmo Sá; Elias, Darcielle Bruna Dias; Cavalcante, Malena Gadelha; Lima, Denise Girão LimaverdeIntroduction: The Brazilian HIV/AIDS management and treatment guideline (PCDT), published in 2013, recommends and standardizes the use of highly active antiretroviral therapy (HAART) in all adult patients, in spite of LTCD4 count. This study aimed to analyze the first year of HAART use in patients from a reference center on HIV/AIDS management in Fortaleza, Ceará. Method: This descriptive study reviewed all pre...
Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell ana...
Pedrosa, Alano Martins; Barbosa, Maritza Cavalcante; Santos, Thayna Nogueira dos; Leal, Luzia Kalyne Almeida Moreira; Lopes, Amanda de AraújoA hidroxiuréia (HU) constitui o avanço mais importante no tratamento da anemia falciforme (AF) por prevenir complicações e aumentar a qualidade de vida dos pacientes. Entretanto, alguns aspectos do tratamento com HU permanecem obscuros, incluindo a sua ação e potencial toxicidade em outras células sanguíneas, tais como neutrófilos. Este estudo utilizou a mensuração da lactato desidrogenase (LDH) e do metil tiaz...
Standardization method for measurement of hydroxyurea by Ultra High Efficiency ...
Elias, Darcielle Bruna Dias; Carvalho, Teresa Maria de Jesus Ponte; Soares, Janete Eliza de Sá; Gonçalves, Romélia PinheiroSickle cell anemia (SCA) is a recessively inherited disease characterized by chronic hemolytic anemia, chronic inflammation, and acute episodes of hemolysis. Hydroxyurea (HU) is widely used to increase the levels of fetal hemoglobin (HbF). The objective of this study was to standardize and validate a method for the quantification of HU in human plasma by using ultra high performance liquid chromatography (UPLC)...
Kidney dysfunction and beta S-haplotypes in patients with sickle cell disease
Rocha, Lilianne Brito da Silva; Silva Junior, Geraldo Bezerra da Silva; Daher, Elizabeth de Francesco; Rocha, Hermano Alexandre LimaObjective: To investigate the association between kidney dysfunction and haplotypes in sickle cell disease. Methods: A cohort of 84 sickle cell disease patients, treated in a public health service in Fortaleza, Brazil, was studied. Hemoglobin S haplotypes were obtained from 57 patients as they had recently received blood transfusions with 18 of them agreeing to undertake urinary concentrating ability and acidif...
Correlation of low levels of nitrite and high levels of fetal hemoglobin in pat...
Elias, Darcielle Bruna Dias; Rocha, Lilianne Brito da Silva; Cavalcante, Maritza Barbosa; Pedrosa, Alano Martins; Justino, Izabel Cristina BandeiraBackground: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. Objective: To evaluate the correlation of the levels of lactate dehydrogenase, malonaldehyde and nitrite to fetal hemoglobin in patients with sickle cell disease not under treatment with hydroxyurea in o...
Avaliação dos níveis séricos de malonaldeído (MDA), óxido nítrico (NO) e lactat...
Elias, Darcielle Bruna DiasThe sickle-cell disease (SCD) is characterized by hemolytic chronic anemia and with vase-occlusive phenomena, followed by target organs which are responsible for the mortality associated with this disease. The vase-occlusive phenomenon is associated with the inflammatory process unleashed by the polymerization of deoxygenated HbS, which favors the polymerization of erythrocytes in the microcirculation and the s...