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Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairment in adu...

Vilela, Márcia Carvalho; Barichello, Tatiana; Generoso, Jaqueline S.; Simões, Lutiana R.; Elias, Samuel G.; Tashiro, Michael H.; Dominguini, Diogo

Streptococcus pneumoniae is a common cause of forms of bacterial meningitis that have a high mortality rate and cause long-term neurologic sequelae. We evaluated the effects of an indoleamine 2,3-dioxygenase (IDO) inhibitor on proinflammatory mediators and memory in Wistar rats subjected to pneumococcal meningitis. The animals were divided into 4 groups: sham, sham treated with IDO inhibitor, meningitis, and me...

Date: 2018   |   Origin: Oasisbr

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