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Time course of the effects of lipopolysaccharide on prepulse inhibition and bra...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Cordeiro, Rafaela Carneiro; Araújo, Fernanda Yvelize Ramos de; Chaves, João HenriqueThe systemic administration of lipopolysaccharide (LPS) induces time-dependent behavioral alterations, which are related to sickness behavior and depression. The time-course effects of LPS on prepulse inhibition (PPI) remain unknown. Furthermore, the time-dependent effects of LPS on central nitrite content had not been investigated. Therefore, we studied alterations induced by single LPS (0.5 mg/kg, i.p.) admin...
Angiotensin receptor blockers for bipolar disorder
Queiroz, Ana Isabelle de Góis; Medeiros, Camila Dantas; Ribeiro, Bruna Mara Machado; Lucena, David Freitas de; Macêdo, Danielle SilveiraStudies have suggested that the brain renin angiotensin system (RAS) regulates cerebral flow, autonomic and hormonal systems, stress, innate immune response and behavior, being implicated in several brain disorders such as major depression, Parkinson’s and Alzheimer’s disease. The angiotensin II receptor sub- type 1 (AT1R) is distributed in brain regions responsible for the control of stress response through pe...
Estudo farmacológico e de alterações neuroquímicas em córtex pré-frontal e corp...
Macêdo, Danielle SilveiraSeizures and death are the most important toxic consequences related to cocaine (COC) overdose. In order to determine the main neurotransmitter systems involved with cocaine-induced seizures, male Swiss mice (20-30 g) were pretreated (i.p.) 15, 30 or 60 min before COC 90 mg/kg administration with drugs that interferes with various neurotransmitter systems. The animals were observed (30 min) to determine: latenc...
Ketamine: general aspects and relationship with schizophrenia
Vasconcelos, Silvânia M. M.; Andrade, Marcelo de Moraes; Soares, Paula Matias; Chaves, Breitner Gomes; Patrocínio, Manoel C. A.Ketamine is an anesthetic agent developed in 1965 by Park & Davis laboratories to be used as a general anesthetic in humans and animals. However, its use became popular among young people and it's frequently available at parties to produce hallucination. In laboratorial researches, this drug has been used as a model of schizophrenia in animals. This work intend to realize a review article about ketamine as an a...