13 documents found, page 1 of 2

Stable variable selection method with shrinkage regression applied to the selec...

In this work, we aimed to establish a stable and accurate procedure with which to perform feature selection in datasets with a much higher number of predictors than individuals, as in genomewide association studies. Due to the instability of feature selection where many potential predictors are measured, a variable selection procedure is proposed that combines several replications of shrinkage regression models...

Assessment of the stability of a procedure for variables selection in high dime...

COPD profiles and treatable traits using minimal resources: Identification, dec...

Background and objective: Profiles of people with chronic obstructive pulmonary disease (COPD) often do not describe treatable traits, lack validation and/or their stability over time is unknown. We aimed to identify COPD profiles and their treatable traits based on simple and meaningful measures; to develop and validate a decision tree and to explore profile stability over time. Methods: An observational, pros...

COPD profiles and treatable traits using minimal resources: identification, dec...

Background and objective: Profiles of people with chronic obstructive pulmonary disease (COPD) often do not describe treatable traits, lack validation and/or their stability over time is unknown. We aimed to identify COPD profiles and their treatable traits based on simple and meaningful measures; to develop and validate a decision tree and to explore profile stability over time. Methods: An observational, pros...

Assessment of the stability of a procedure for variables selection in high dime...

No abstract available.

The genomics facility of iBiMED: bioinformatics lab

The Genomics facility of iBiMED (iBiGEN), provides genomics services, including bioinformatics and statistical analysis to iBiMED researchers, and to external users. Since our start, in 2018, the bioinformatic lab have carried out 52 studies at a genomic scale, including de novo genome sequencing with variant detection (SNPs, indels, CNVs, LOH), whole exome or gene panel sequencing, RNA sequencing analysis (tot...

COPD profiles and treatable traits using minimal resources: Identification, dec...

Background: Chronic obstructive pulmonary disease (COPD) is highly heterogeneous and complex. Hence, personalising assessments and treatments to this population across different settings and available resources imposes challenges and debate. Research efforts have been made to identify clinical phenotypes or profiles for prognostic and therapeutic purposes. Nevertheless, such profiles often do not describe treat...

Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestroge...

The protein quality control network, including autophagy, the proteasome and the unfolded protein response (UPR), is triggered by stress and is overactive in acquired antiestrogen therapy resistance. We show for the first time that the aggresome load correlates with apoptosis and is increased in antiestrogen-sensitive cells compared to endocrine-resistant variants. LC-MS/MS analysis of the aggregated proteins o...

Clinical characteristics of COPD Phenotypes

Exploring the clinics of chronic obstructive pulmonary disease using multiple c...

No abstract available