13 documents found, page 1 of 2
Design, synthesis and biological evaluation of N-oxide derivatives with potent ...
da Costa Clementino, Leandro [UNESP]; Fernandes, Guilherme Felipe Santos [UNESP]; Prokopczyk, Igor Muccilo [UNESP]; Laurindo, Wilquer Castro [UNESP]Made available in DSpace on 2022-05-01T10:03:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Leishmaniasis is a neglected disease that affects 12 million people living mainly in developing countr...
Pharmacognosy Can natural products improve skin photoprotection?
Chiari-Andréo, Bruna Galdorfini [UNESP]; de Almeida, Fernanda Borges [UNESP]; Yamasaki, Paulo Renato [UNESP]; dos Santos, Jean Leandro [UNESP]Made available in DSpace on 2021-06-25T11:02:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-07-01; Due to increased UV radiation on the Earth’s surface, caused by depletion of the stratospheric ozone, people have become more susceptible to different types of skin damage, such as erythema, sunburns, and cancer; this is especially of concern in tropical countries. Thus, efforts to improve awareness as ...
Synthesis and pharmacological evaluation of pomalidomide derivatives useful for...
de Melo, Thais Regina Ferreira [UNESP]; Dulmovits, Brian; Fernandes, Guilherme Felipe dos Santos [UNESP]; de Souza, Cristiane M.; Lanaro, CarolinaMade available in DSpace on 2021-06-25T10:32:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01; Fetal hemoglobin (HbF) induction constitutes a valuable and validated approach to treat the symptoms of sickle cell disease (SCD). Here, we synthesized pomalidomide–nitric oxide (NO) donor derivatives (3a–f) and evaluated their suitability as novel HbF inducers. All compounds demonstrated different capa...
Synthesis and anti-inflammatory intestinal activity of new glucocorticoid deriv...
Machado, Marcella Gabrielle Mendes [UNESP]; Scarim, Cauê Benito [UNESP]; de Andrade, Cleverton Roberto [UNESP]; dos Santos, Jean Leandro [UNESP]Made available in DSpace on 2020-12-12T02:30:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01; Glucocorticoids (GCs) are used worldwide in the treatment of chronic inflammatory diseases. This study describes the synthesis of new glucocorticoid derivatives and evaluates anti-inflammatory activity in rat models with ulcerative colitis (UC). Six compounds (5a–f) were synthetized using the molecular ...
Dietary compound resveratrol is a pan-BET bromodomain inhibitor
Dutra, Luiz Antonio [UNESP]; Heidenreich, David; da Silva, Gabriel Dalio Bernardes [UNESP]; Chin, Chung Man [UNESP]; Knapp, StefanMade available in DSpace on 2018-12-11T17:34:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-11-01; The chemopreventive and anticancer effects of resveratrol (RSV) are widely reported in the literature. Specifically, mechanisms involving epigenetic regulation are promising targets to regulate tumor development. Bromodomains act as epigenetic readers by recognizing lysine acetylation on histone tails a...
In vivo antileishmanial activity and histopathological evaluation in Leishmania...
de Almeida, Letícia [UNESP]; Passalacqua, Thaís Gaban [UNESP]; Dutra, Luiz Antonio [UNESP]; Fonseca, Jéssica N. Varonez da [UNESP]Made available in DSpace on 2018-12-11T16:49:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); N-oxide derivatives compounds such as furoxan and benzofuroxan are promising scaffolds for designing of new antileishmanial drugs. A series of furoxan (1,2,5-oxadiazole 2-...
Synthesis and biological activity of furoxan derivatives against Mycobacterium ...
Fernandes, Guilherme Felipe dos Santos [UNESP]; de Souza, Paula Carolina [UNESP]; Marino, Leonardo Biancolino [UNESP]; Chegaev, KonstantinMade available in DSpace on 2018-12-11T17:29:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Tuberculosis (TB) remains a serious health problem responsible to cause millions of deaths annually. The scenario becomes alarming when it is evaluated that the number of new drugs does not increase proportionally to the emergence of resista...
Advances in drug design based on the amino acid approach: Taurine analogues for...
Chung, Man Chin [UNESP]; Malatesta, Pedro [UNESP]; Bosquesi, Priscila Longhin [UNESP]; Yamasaki, Paulo Renato [UNESP]; dos Santos, Jean Leandro [UNESP]Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:27:06Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:42:27Z : No. of bitstreams: 1 2-s2.0-84869206693.pdf: 345052 bytes, checksum: af1f663f5bb60b9d0121f6ed18b7e210 (MD5); Made available in DSpace on 2014-05-27T11:27:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-10-23; Amino acids are well known to be an...
Assessment of the In Vivo Genotoxicity of New Lead Compounds to Treat Sickle Ce...
dos Santos, Jean Leandro [UNESP]; Bosquesi, Priscila Longhin [UNESP]; Varanda, Eliana Aparecida [UNESP]; Lima, Lidia Moreira [UNESP]Made available in DSpace on 2013-08-28T14:10:45Z (GMT). No. of bitstreams: 1 WOS000289236200018.pdf: 135142 bytes, checksum: 7f8ac6824bf87dea39d0f755db9195a5 (MD5); Made available in DSpace on 2013-09-30T18:06:14Z (GMT). No. of bitstreams: 2 WOS000289236200018.pdf: 135142 bytes, checksum: 7f8ac6824bf87dea39d0f755db9195a5 (MD5) WOS000289236200018.pdf.txt: 19979 bytes, checksum: b27b5f440ca075f5efd7a522fdf2d92f (...
Mutagenicity of New Lead Compounds to Treat Sickle Cell Disease Symptoms in a S...
dos Santos, Jean Leandro [UNESP]; Varanda, Eliana Aparecida [UNESP]; Lima, Lidia Moreira; Chin, Chung Man [UNESP]Made available in DSpace on 2013-09-27T14:53:43Z (GMT). No. of bitstreams: 1 WOS000274973500024.pdf: 195413 bytes, checksum: bad576d09aca85b53b19c1f1893fc1d8 (MD5) Previous issue date: 2010-02-01; Made available in DSpace on 2013-09-30T18:06:20Z (GMT). No. of bitstreams: 1 WOS000274973500024.pdf: 195413 bytes, checksum: bad576d09aca85b53b19c1f1893fc1d8 (MD5) Previous issue date: 2010-02-01; Submitted by Vitor S...