Encontrados 5 documentos, a visualizar página 1 de 1
An instructive role for Interleukin-7 receptor α in the development of human B-...
Geron, Ifat; Savino, Angela Maria; Fishman, Hila; Tal, Noa; Brown, John; Turati, Virginia A.; James, Chela; Sarno, Jolanda; Hameiri-Grossman, MichalKinase signaling fuels growth of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Yet its role in leukemia initiation is unclear and has not been shown in primary human hematopoietic cells. We previously described activating mutations in interleukin-7 receptor alpha (IL7RA) in poor-prognosis "ph-like" BCP-ALL. Here we show that expression of activated mutant IL7RA in human CD34+ hematopoietic stem and p...
Advances and challenges in retinoid delivery systems in regenerative and therap...
Ferreira, Raquel; Napoli, Joseph; Enver, Tariq; Bernardino, Liliana; Ferreira, LinoRetinoids regulate a wide spectrum of cellular functions from the embryo throughout adulthood, including cell differentiation, metabolic regulation, and inflammation. These traits make retinoids very attractive molecules for medical purposes. In light of some of the physicochemical limitations of retinoids, the development of drug delivery systems offers several advantages for clinical translation of retinoid-b...
Prolonged intracellular accumulation of light-inducible nanoparticles in leukem...
Boto, Carlos; Quartin, Emanuel; Cai, Yijun; Martín-Lorenzo, Alberto; Cenador, María Begoña García; Pinto, Sandra; Gupta, Rajeev; Enver, TariqLeukaemia cells that are resistant to conventional therapies are thought to reside in protective niches. Here, we describe light-inducible polymeric retinoic acid (RA)-containing nanoparticles (NPs) with the capacity to accumulate in the cytoplasm of leukaemia cells for several days and release their RA payloads within a few minutes upon exposure to blue/UV light. Compared to NPs that are not activated by light...
Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self-Renewal of Mou...
Kranc, Kamil R.; Oliveira, Daniel; Armesilla-Diaz, Alejandro; Pacheco-Leyva, Ivette; Matias, Ana Catarina; Escapa, Ana Luísa; Subramani, ChithraIdentifying novel players of the pluripotency gene regulatory network centered on Oct4, Sox2, and Nanog as well as delineating the interactions within the complex network is key to understanding self-renewal and early cell fate commitment of embryonic stem cells (ESC). While overexpression of the transcriptional regulator Cited2 sustains ESC pluripotency, its role in ESC functions remains unclear. Here, we show...
Mitochondrial variability as a source of extrinsic cellular noise
Johnston, Iain G; Gaal, Bernadett; Neves, Ricardo Pires das; Enver, Tariq; Iborra, Francisco J; Jones, Nick SWe present a study investigating the role of mitochondrial variability in generating noise in eukaryotic cells. Noise in cellular physiology plays an important role in many fundamental cellular processes, including transcription, translation, stem cell differentiation and response to medication, but the specific random influences that affect these processes have yet to be clearly elucidated. Here we present a m...