3 documents found, page 1 of 1
Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal can...
Almeida, Maria L.; Nicoloso, Milena S.; Zeng, Lizhi; Ivan, Cristina; Spizzo, Riccardo; Gafà, Roberta; XIiao, LIianchun; Zhang, Xinna; Vanninii, IvanBackground & Aims MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p and 3p, that can bind different mRNAs. We analyzed the expression, functions, and mechanisms ...
Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in ...
Le, Xiao-Fen; Almeida, Maria Inês; Mao, Weiqu; Spizzo, Riccardo; Rossi, Simona; Nicoloso, Milena S.; Zhang, Shu; Wu, Yun; Calin, George A.Trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of the HER2 oncoprotein, can effectively target HER2-positive breast cancer through several mechanisms. Although the effects of trastuzumab on cancer cell proliferation, angiogenesis and apoptosis have been investigated in depth, the effect of trastuzumab on microRNA (miRNA) has not been extensively studied. We have performed...
Long non-coding RNAs and cancer: a new frontier of translational research?
Spizzo, Riccardo; Almeida, Maria Inês; Colombatti, A.; Calin, George A.Tiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes, particularly those involved in disease, are still a matter of debate. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in cancer. We define lncRNAs...