6 documents found, page 1 of 1
Fostering conservancy through bioprospection: the pharmaceutical value of the b...
Sahm, Bianca Del Bianco; Guimarães, Larissa Alves; Wilke, Diego Veras; Bauermeister, Anelize; Costa-Lotufo, Leticia Veras; Jimenez, Paula C.The inherent value of nature is immeasurable. That being said, through bioprospection – the systematic search for functional products or processes from living organisms –, the oceans and marine life have emerged as a relevant source of biodiscoveries that hold significant economic worth. Particularly considering the pharmaceutical industry, an increasing number of natural molecules of marine origin have been ma...
A proline derivative-enriched methanol fraction from Sideroxylon obtusifolium l...
Souza, Tamiris F. G.; Pierdoná, Taiana M.; Macedo, Fernanda Soares; Aquino, Pedro E. A.; Rangel, Gisele F. P.; Duarte, Rebeca S.; Silva, Lorena Mara A.It was previously demonstrated that the methanol fraction of Sideroxylon obtusifolium (MFSOL) promoted anti-inflammatory and healing activity in excisional wounds. Thus, the present work investigated the healing effects of MFSOL on human keratinocyte cells (HaCaT) and experimental burn model injuries. HaCaT cells were used to study MFSOL’s effect on cell migration and proliferation rates. Female Swiss mice were...
Marine drugs for cancer: surfacing biotechnological innovations from the oceans
Jimenez, Paula Christine; Wilke, Diego Veras; Costa-Lotufo, Leticia VerasThis review will discuss the contributions of marine natural molecules, a source only recently found to have pharmaceutical prospects, to the development of anticancer drugs. Of the seven clinically utilized compounds with a marine origin, four are used for the treatment of cancer. The development of these drugs has afforded valuable knowledge and crucial insights to meet the most common challenges in this ende...
Crotalus durissus cascavella venom toxicity to mammalian cells
Araújo, Lucelina da Silva; Rocha, Danilo Damasceno; Viana, Daniel Araújo; Silveira, João Alison de Moraes; Vasconcelos-Filho, Francisco Sérgio LopesSnakes from the genus Crotalus gained significant space in the scientific field since the development of researches with their venom involving cytotoxic activity. Crotalus durissus cascavella is the only subspecies recorded of the Caatinga biome of Northeastern Brazil and it’s noticed a lack of studies on its venom properties. The present study evaluated the crude venom of C. d. cascavella for its cytotoxic act...
Chromomycin A2 induces autophagy in melanoma cells
Guimarães, Larissa Alves; Jimenez, Paula Christine; Sousa, Thiciana da Silva; Freitas, Hozana Patrícia S.; Rocha, Danilo Damasceno; Wilke, Diego VerasThe present study highlights the biological effects of chromomycin A2 toward metastatic melanoma cells in culture. Besides chromomycin A2, chromomycin A3 and demethylchromomycin A2 were also identified from the extract derived from Streptomyces sp., recovered from Paracuru Beach, located in the northeast region of Brazil. The cytotoxic activity of chromomycin A2 was evaluated across a panel of human tumor cell ...
Estudo do potencial anticâncer de substâncias obtidas do zoantídeo Protopalytho...
Wilke, Diego VerasCancer is one of the biggest health problems in all over the world and causes a great amount of death of children and adults. Despite success of several cancer therapies, the ideal anticancer drug is not available yet and the numerous side effects are a limiting point. The natural products research, although recent, has shown often a variety of new chemical structures and potent biological activities. Cytotoxic...