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Longitudinally aligned inner-patterned silk fibroin conduits for peripheral ner...

Escobar Fernandez, Ane; Carvalho, Mariana R.; Silva, Tiago H.; Reis, R. L.; Oliveira, Joaquim M.

Peripheral nerve injuries represent a major clinical challenge, if nerve ends retract, there is no spontaneous regeneration, and grafts are required to proximate the nerve ends and give continuity to the nerve. The nerve guidance conduits (NGCs) presented in this work are silk fibroin (SF)-based, which is biocompatible and very versatile. The formation of conduits is obtained by forming a covalently cross-linke...


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