4 documents found, page 1 of 1
Height Benefit of GnRH Agonists After Age 8 in a Portuguese Cohort of Central P...
Castro, C; Espada, F; Leite, AL; Antunes, A; Robalo, B; Amaral, D; Galo, E; Castro, S; Ferreira, S; Limbert, CObjective: Idiopathic central precocious puberty (iCPP) is common in paediatric endocrinology. Gonadotropin-releasing hormone agonists (GnRHa) are safe, but the effect on final height and the ideal timing for treatment remains controversial. This study aims to assess the effectiveness of GnRHa on growth outcomes in girls with iCPP treated before and after the age of 8 years old. Design and patients: This retros...
Do GnRH Agonists Really Increase Body Weight Gain? Evaluation of a Multicentric...
Leite, AL; Galo, E; Antunes, A; Robalo, B; Amaral, D; Espada, F; Castro, S; Simões Dias, S; Limbert, CIntroduction: There are several concerns associated with gonadotropin-releasing hormone agonist (GnRHa) treatment for central precocious puberty (CPP), such as obesity and changes in body mass index (BMI). We aimed to investigate whether any anthropometric differences exist and if they persist over time. Methods: We conducted an observational study of Portuguese children (both sexes) diagnosed with CPP between ...
CYP21A2 Gene Pathogenic Variants: A Multicenter Study on Genotype-Phenotype Cor...
Santos-Silva, R; Cardoso, R; Lopes, L; Fonseca, M; Espada, F; Sampaio, L; Brandão, C; Antunes, A; Bragança, G, et al.BACKGROUND: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder characterized by 3 overlapping phenotypes: salt-wasting (SW), simple virilizing (SV), and non-classic (NC). We aimed at conducting a nationwide genotype description of the CAH pediatric patients and to establish their genotype-phenotype correlation. METHODS: CAH patients were recruited fr...
Treatment of Pediatric Graves Disease: results of a multicenter survey in Portugal
Marques, O; Oliveira, MJ; Antunes, A; Espada, F; Guimarães, J; Portuguese Endocrinology and Diabetes Pediatric Society (SPEDP)