2 documents found, page 1 of 1
Predictive Factors for PCR and Relapse Following Neoadjuvant Dual HER2-Blockade...
Luz, Paulo; Lopes-Brás, Raquel; Pinho, Inês Soares; Patel, Vanessa; Esperança-Martins, Miguel; Gonçalves, Lisa; Gonçalves, Joana; Freitas, RitaPurpose: Neoadjuvant systemic therapy with dual HER2-blockade, trastuzumab and pertuzumab, combined with chemotherapy has become a standard approach in patients with HER2-positive (HER2+) breast cancer (BC). However, the variability in treatment outcomes, such as pathological complete response (pCR) or relapse rates, underscores the need to identify predictive factors to optimize therapeutic strategies. This st...
On the Relevance of Soft Tissue Sarcomas Metabolic Landscape Mapping
Esperança-Martins, Miguel; F. Duarte, Iola; Rodrigues, Mara; Soares do Brito, Joaquim; López-Presa, Dolores; Costa, Luís; Fernandes, IsabelSoft tissue sarcomas (STS) prognosis is disappointing, with current treatment strategies being based on a "fit for all" principle and not taking distinct sarcoma subtypes specificities and genetic/metabolic differences into consideration. The paucity of precision therapies in STS reflects the shortage of studies that seek to decipher the sarcomagenesis mechanisms. There is an urge to improve STS diagnosis preci...