24 documents found, page 1 of 3
Biodegradable nanoparticles for the treatment of epilepsy: From current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Lipid nanoparticles for the posterior eye segment
Bonilla, Lorena; Espina, Marta; Severino, Patricia; Cano, Amanda; Ettcheto, Miren; Camins, Antoni; García, Maria Luisa; Souto, Eliana B.This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles wil...
Biodegradable nanoparticles for the treatment of epilepsy: from current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Th...
Petit, Robert Gironés; Cano, Amanda; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Severino, Patrícia; Souto, Eliana B.Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecula...
State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparti...
García-Torra, Victor; Cano, Amanda; Espina, Marta; Ettcheto, Miren; Camins, Antoni; Barroso, Emma; Vazquez-Carrera, Manel; García, Maria LuisaMetal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of...
Surface Functionalization of PLGA Nanoparticles to Increase Transport across th...
Del Amo, Laura; Cano, Amanda; Ettcheto, Miren; Souto, Eliana B.; Espina, Marta; Camins, Antoni; García, Maria Luísa; Sánchez-López, ElenaAlzheimer’s disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. N...
Surface functionalization of PLGA nanoparticles to increase transport across th...
Del Amo, Laura; Cano, Amanda; Ettcheto, Miren; Souto, Eliana B.; Espina, Marta; Camins, Antoni; García, Maria Luísa; Sánchez-López, ElenaAlzheimers disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Na...
Development of topical eye-drops of lactoferrin-loaded biodegradable nanopartic...
López-Machado, Ana; Díaz, Natalia; Cano, Amanda; Espina, Marta; Badía, Josefa; Baldomà, Laura; Calpena, Ana Cristina; Biancardi, MartinaOcular inflammation is one of the most common comorbidities associated to ophthalmic surgeries and disorders. Since conventional topical ophthalmic treatments present disadvantages such as low bioavailability and relevant side effects, natural alternatives constitute an unmet medical need. In this sense, lactoferrin, a high molecular weight protein, is a promising alternative against inflammation. However, lact...
Diabetic Retinopathy and Ocular Melanoma: How Far We Are?
Souto, Eliana B.; Campos, Joana R.; Ana, Raquel da; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, MassimoDiabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal m...
Metal-Based Nanoparticles as Antimicrobial Agents: An Overview
Sánchez-López, Elena; Gomes, Daniela; Esteruelas, Gerard; Bonilla, Lorena; Lopez-Machado, Ana Laura; Galindo, Ruth; Cano, Amanda; Espina, MartaMetal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to ...