5 documents found, page 1 of 1
Biodegradable nanoparticles for the treatment of epilepsy: From current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Biodegradable nanoparticles for the treatment of epilepsy: from current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Metal-Based Nanoparticles as Antimicrobial Agents: An Overview
Sánchez-López, Elena; Gomes, Daniela; Esteruelas, Gerard; Bonilla, Lorena; Lopez-Machado, Ana Laura; Galindo, Ruth; Cano, Amanda; Espina, MartaMetal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to ...
Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocul...
Sánchez-López, Elena; Esteruelas, Gerard; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Cano, Amanda; Calpena, Ana CristinaOcular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradab...
Metal-based nanoparticles as antimicrobial agents: an overview
Sánchez-López, Elena; Gomes, Daniela; Esteruelas, Gerard; Bonilla, Lorena; Lopez-Machado, Ana Laura; Galindo, Ruth; Cano, Amanda; Espina, MartaMetal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to ...