10 documents found, page 1 of 1
Neuronal control of microglia through the mitochondria
Pereira-Santos, A. R.; Candeias, Emanuel; Magalhães, J. D.; Empadinhas, Nuno; Esteves, A. Raquel; Cardoso, Sandra MoraisThe microbial toxin β-N-methylamino-L-alanine (BMAA), which is derived from cyanobacteria, targets neuronal mitochondria, leading to the activation of neuronal innate immunity and, consequently, neurodegeneration. Although known to modulate brain inflammation, the precise role of aberrant microglial function in the neurodegenerative process remains elusive. To determine if neurons signal microglial cells, we tr...
The Role of Bacteria-Mitochondria Communication in the Activation of Neuronal I...
Magalhães, João Duarte; Esteves, A. Raquel; Candeias, Emanuel; Silva, Diana F. F.; Empadinhas, Nuno; Cardoso, Sandra MoraisMitochondria play a key role in regulating host metabolism, immunity and cellular homeostasis. Remarkably, these organelles are proposed to have evolved from an endosymbiotic association between an alphaproteobacterium and a primitive eukaryotic host cell or an archaeon. This crucial event determined that human cell mitochondria share some features with bacteria, namely cardiolipin, N-formyl peptides, mtDNA and...
The Impact of microRNAs on Mitochondrial Function and Immunity: Relevance to Pa...
Guedes, Beatriz F. S.; Cardoso, Sandra M.; Esteves, A. RaquelParkinson's Disease (PD), the second most common neurodegenerative disorder, is characterised by the severe loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc) and by the presence of Lewy bodies. PD is diagnosed upon the onset of motor symptoms, such as bradykinesia, resting tremor, rigidity, and postural instability. It is currently accepted that motor symptoms are preceded by non-motor f...
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitoch...
Esteves, A. Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F. F.; Magalhães, João Duarte; Santos, A. Raquel PereiraObjective Idiopathic Parkinson’s disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N- methylamino- L- al...
LPS-induced mitochondrial dysfunction regulates innate immunity activation and ...
Esteves, A. Raquel; Silva, Diana F. F.; Banha, Diogo; Candeias, Emanuel; Guedes, Beatriz; Cardoso, Sandra M.Sporadic Parkinson's disease (sPD) is a complex multifactorial disorder which etiology remains elusive. Several mechanisms have been described to contribute to PD development namely mitochondrial dysfunction, activation of inflammatory pathways and the deposition of unfolded proteins such as α-synuclein. Our work shows for the first time that lipopolysaccharide (LPS)-induced activation of innate immunity requir...
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitoch...
Esteves, A. Raquel; Munoz-Pinto, Mário F.; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F.; Magalhães, João D.; Pereira-Santos, A. RaquelIdiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N-methylamino-L-alanine (BMAA) ...
Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole...
Keri, Rangappa S.; Quintanova, Catarina; Marques, Sérgio M.; Esteves, A. Raquel; Cardoso, Sandra M.; Santos, M. AméliaAlzheimer’s disease (AD) is a multifactorial disorder with several target proteins contributing to its etiology. In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Aβ) aggregation are particularly important targets for inhibition, the tacrine and benzothiazole (BTA) moieties were conjugated with suitable linkers in a novel series of ...
Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: w...
Arduíno, Daniela M.; Esteves, A. Raquel; Cardoso, Sandra M.Understanding the molecular basis of Parkinson's disease (PD) has proven to be a major challenge in the field of neurodegenerative diseases. Although several hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of PD, a growing body of evidence has highlighted the role of mitochondrial dysfunction and the disruption of the mechanisms of mitochondrial dynamics in PD and o...
Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis
Branco, Diogo Martins; Arduíno, Daniela M.; Esteves, A. Raquel; Silva, Diana F. F.; Cardoso, Sandra M.; Oliveira, C. R.Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading hypothesis for the death of specific groups of neurons establishes that mitochondrial dysfunctio...
ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 n...
Arduíno, Daniela M.; Esteves, A. Raquel; Domingues, A. Filipa; Pereira, Cláudia M. F.; Cardoso, Sandra M.; Oliveira, C. R.Recent studies have revealed that endoplasmic reticulum (ER) disturbance is involved in the pathophysiology of neurodegenerative disorders, contributing to the activation of the ER stress-mediated apoptotic pathway. Therefore, we investigated here the molecular mechanisms underlying the ER-mitochondria axis, focusing on calcium as a potential mediator of cell death signals. Using NT2 cells treated with brefeldi...