45 documents found, page 1 of 5
Ionic liquids for the electroreductive radical cyclization of unsaturated bromo...
Neto, M. J.; Duñach, E.; Esperança, J. M. S. S.; Esteves, Ana Paula; Medeiros, Maria José; Silva, Maria ManuelaRoom temperature ionic liquids, such as N,N,N-trimethyl-N-(2-hydroxyethyl)ammonium bis(trifluoromethylsulfonyl)imide, [N1 1 1 2(OH)][NTf2] and 1-ethyl-3-methylimidazolium ethylsulfate, [C2mim][C2SO4], have been used for the electroreductive intramolecular cyclization of unsaturated bromo derivatives 1 in Ni(II)-catalyzed reactions. Controlled-potential electrolyses led to five-membered-ring compounds in moderate ...
Synthesis of five-membered heterocycles by indirect electrochemical approach in...
Duraes, C.; Lombard, J.; Pereira, S.; Esteves, Ana Paula; Medeiros, Maria JoséRadical cyclization continues to be a central methodology for the preparation of natural products containing heterocyclic rings. Hence, some electrochemical results obtained by cyclic voltammetry and controlled-potential electrolysis in the study of electroreductive intramolecular cyclization of ethyl (2S, 3R)-2-bromo-3-propargyloxy-3-(2’,3’,4’,6’-tetra-O-acetyl-beta-D-glucopyranosyloxy) propanoate (1a), 2-brom...
Study of the electrochemical reduction of amoebicide Teclozan and its amperomet...
Santos, Andri L.; Takeuchi, Regina M. [UNESP]; Stradiotto, Nelson Ramos [UNESP]; Esteves, Ana Paula; Medeiros, Maria JoseMade available in DSpace on 2013-08-12T18:43:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-01-01; Made available in DSpace on 2013-09-30T19:08:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-01-01; Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:19:17Z No. of bitstreams: 0; Made available in DSpace on 2014-05-20T14:19:17Z (GMT). No. of bitstreams:...
Ciência dos 3 aos 11: atividades experimentais de física e de química
Costa, Manuel F. M.; Varela, Paulo Idalino Balça; Pereira, Mário R.; Tovar, J.; Franco, Sandra; Geraldo, M. Dulce; Esteves, Ana Paula; Bento, M. FátimaCurso Pri-Sci-Net de Formação de Professores (Portugal). Professores do Ensino Pré-Escolar (grupo 100), do 1º (grupo 110) e do 2º Ciclos (grupo 230) do Ensino Básico.
The study of indirect electroreductive cyclization of propargyl derivatives usi...
Neto, M. J.; Esperança, J. M. S. S.; Esteves, Ana Paula; Medeiros, Maria José; Silva, Maria ManuelaRadical cyclization continues to be a central methodology for the preparation of natural products containing heterocyclic rings. The use of electrogenerated nickel(I) complexes as mediators for cathodic intramolecular cyclizations proved to be successful in the formation of carbocyclic products. In this work, the indirect electroreductive intramolecular cyclization of bromoalkoxylated derivatives 1 catalyzed by...
Novel benzopsoralen analogues : synthesis, biological activity and molecular do...
Francisco, Carla Santana; Rodrigues, L. R.; Cerqueira, N. M. F. S. A.; Campos, Ana M. F. Oliveira; Esteves, Ana PaulaNew benzopsoralen analogues were synthesized and their inhibitory effect on the growth of tumourtumour cell lines (MDA MB231 and TCC-SUP) was evaluated. The in vitro antitumour activity of the new benzopsoralen analogues was discussed in terms of structure–activity relationship. Molecular docking studies with human-CYP2A6 enzymes were also carried out with the synthesized compounds to evaluate the potential of ...
Synthesis of novel Glycoconjugates derived from Alkynyl heterocycles through a ...
Silva, Marília E.; Gonçalves, João Carlos Oliveira; Campos, Ana M. F. Oliveira; Rodrigues, Lígia M.; Esteves, Ana PaulaAccepted author version posted online: 05 Jun 2012; The synthesis of a series of novel 1,4-disubstituted 1,2,3-triazole compounds bearing a D-glucose derivative and an heteroaromatic system is described. Alkylation of isatin, 3-methyl-carbazole and one tetrahydro-gamma-carboline with propargyl bromide gave their N-propargyl derivatives in good yields. These compounds further reacted with acetylated D-glucose wi...
Synthesis of glycoconjugates containing a 1,2,3-triazole unit
Cunha, Sandra Raquel Leite; Pereira, S.; Malheiro, M.; Rodrigues, Lígia M.; Campos, Ana M. F. Oliveira; Esteves, Ana PaulaThe preparation of several alkynyl esters, derived from amino acids, coumarins and an alkynyl derivative of acetylated D-glucose is described. Eight new glycoconjugates containing the 1,2,3-triazole unit were obtained, by a click approach from the above referred alkynyl derivatives with tetracetyl-beta-D-glucosylazide, prepared in situ from alpha-acetobromoglucose.; Foundation for the Science and Technology (FC...
Synthesis of novel psoralen analogues and their in vitro antitumor activity
Francisco, Carla Santana; Rodrigues, L. R.; Cerqueira, N. M. F. S. A.; Campos, Ana M. F. Oliveira; Rodrigues, Lígia M.; Esteves, Ana PaulaNew tetracyclic benzofurocoumarin (benzopsoralen) analogues were synthesized and their inhibitory effect on the growth of tumor cell lines was evaluated. The human tumor cell lines used were MDA MB231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma). The in vitro antitumor activity of the new benzopsoralens was discussed in terms of structure–activity relat...
Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxy...
Heleno, Sandrina A.; Ferreira, Isabel C. F. R.; Esteves, Ana Paula; Ćirić, Ana; Glamočlija, Jasmina; Martins, Anabela; Soković, MarinaMushroom extracts or isolated compounds may be useful in the search of new potent antimicrobial agents. Herein, it is described the synthesis of protected (acetylated) glucuronide derivatives of p-hydroxybenzoic and cinnamic acids, two compounds identified in the medicinal mushroom Ganoderma lucidum. Their antimicrobial and demelanizing activities were evaluated and compared to the parent acids and G. lucidum e...