3 documents found, page 1 of 1
Probability distribution of copy number alterations along the genome: an algori...
Esteves, Luísa; Caramelo, Francisco; Ribeiro, Ilda Patrícia; Carreira, Isabel M.; Melo, Joana Barbosa deCopy number alterations (CNAs) comprise deletions or amplifications of fragments of genomic material that are particularly common in cancer and play a major contribution in its development and progression. High resolution microarray-based genome-wide technologies have been widely used to detect CNAs, generating complex datasets that require further steps to allow for the determination of meaningful results. In ...
Genomic and epigenetic signatures associated with survival rate in oral squamou...
Ribeiro, Ilda Patrícia; Caramelo, Francisco; Esteves, Luísa; Oliveira, Camila; Marques, Francisco; Barroso, Leonor; Melo, Joana BarbosaPurpose: Although oral squamous cell carcinoma (OSCC) presents great mortality and morbidity worldwide, the mechanisms behind its clinical behavior remain unclear. Biomarkers are needed to forecast patients' survival and, among those patients undergoing curative therapy, which are more likely to develop tumor recurrence/metastasis. Demonstrating clinical relevance of these biomarkers could be crucial both for s...
Genomic predictive model for recurrence and metastasis development in head and ...
Ribeiro, Ilda Patrícia; Caramelo, Francisco; Esteves, Luísa; Menoita, Joana; Marques, Francisco; Barroso, Leonor; Miguéis, Jorge; Melo, Joana BarbosaThe head and neck squamous cell carcinoma (HNSCC) population consists mainly of high-risk for recurrence and locally advanced stage patients. Increased knowledge of the HNSCC genomic profile can improve early diagnosis and treatment outcomes. The development of models to identify consistent genomic patterns that distinguish HNSCC patients that will recur and/or develop metastasis after treatment is of utmost im...